Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination

Brain-derived neurotrophic factor (BDNF) is involved in neuronal and glial development and survival. While neurons and astrocytes are its main cellular source in the central nervous system (CNS), bioactive BDNF is also expressed in immune cells and in lesions of multiple sclerosis and its animal mod...

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Veröffentlicht in:	Acta neuropathologica 2012-02, Vol.123 (2), p.247-258
Hauptverfasser:	Lee, De-Hyung, Geyer, Eva, Flach, Anne-Christine, Jung, Klaus, Gold, Ralf, Flügel, Alexander, Linker, Ralf A., Lühder, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Astrocytes Axons - immunology Axons - metabolism Axons - pathology Bone marrow Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - deficiency Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - physiology Cell survival Central nervous system Central Nervous System - immunology Central Nervous System - metabolism Central Nervous System - pathology Chimeras copolymer 1 Data processing Demyelination Development Disease Models, Animal Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Female Immune system Immunosuppressive agents Lymphocytes Male Medical research Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Multiple sclerosis Myelin Nerve Degeneration - immunology Nerve Degeneration - metabolism Nerve Degeneration - pathology Nervous system Neuronal-glial interactions Neurons Neuroprotection Neurosciences Oligodendrocytes Original Paper Pathology Primary Cell Culture Proteins Radiation Chimera
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