Modification of Drosophila p53 by SUMO Modulates Its Transactivation and Pro-apoptotic Functions

Conjugation to SUMO is a reversible post-translational modification that regulates several transcription factors involved in cell proliferation, differentiation, and disease. The p53 tumor suppressor can be modified by SUMO-1 in mammalian cells, but the functional consequences of this modification a...

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Veröffentlicht in:	The Journal of biological chemistry 2008-07, Vol.283 (30), p.20848-20856
Hauptverfasser:	Mauri, Federico, McNamee, Laura M., Lunardi, Andrea, Chiacchiera, Fulvio, Del Sal, Giannino, Brodsky, Michael H., Collavin, Licio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Animals, Genetically Modified Apoptosis Cell Differentiation Cell Proliferation Drosophila - metabolism Models, Biological Mutation Nuclear Proteins - metabolism Protein Structure, Tertiary Protein Synthesis, Post-Translational Modification, and Degradation RNA, Messenger - metabolism Small Ubiquitin-Related Modifier Proteins - metabolism Transcriptional Activation Tumor Suppressor Protein p53 - metabolism
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