Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs

Common themes are emerging in the molecular mechanisms of long non-coding RNA-mediated gene repression. Long non-coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of g...

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Veröffentlicht in:	BioEssays 2011-11, Vol.33 (11), p.830-839
Hauptverfasser:	Saxena, Alka, Carninci, Piero
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly Epigenesis, Genetic Gene Expression Regulation Gene Silencing Genome, Human Histones - genetics Histones - metabolism Humans Methyl-CpG-Binding Protein 2 - genetics Methyl-CpG-Binding Protein 2 - metabolism Mice Neoplasms - genetics Neoplasms - metabolism Promoter Regions, Genetic Prospects & Overviews Rett Syndrome - genetics Rett Syndrome - metabolism RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA, Untranslated - genetics RNA, Untranslated - metabolism Transcription, Genetic
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