Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration

A dinucleotide deletion in human ubiquitin (Ub) B messenger RNA leads to formation of polyubiquitin (UbB)+1, which has been implicated in neuronal cell death in Alzheimer's and other neurodegenerative diseases. Previous studies demonstrate that UbB+1 protein causes proteasome dysfunction. Howev...

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Veröffentlicht in:	Cell death and differentiation 2007-10, Vol.14 (10), p.1721-1732
Hauptverfasser:	Tan, Z, Sun, X, Hou, F-S, Oh, H-W, Hilgenberg, L G W, Hol, E M, van Leeuwen, F W, Smith, M A, O'Dowd, D K, Schreiber, S S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Animals Apoptosis Base Sequence Biochemistry Biomedical and Life Sciences Cell Biology Cell cycle Cell Cycle Analysis Cell death Cell division Cell Line, Tumor Cells, Cultured Disease Endoplasmic reticulum Enzymes Female Gene Expression Regulation - drug effects Life Sciences Mice Mice, Inbred C57BL Microscopy Microtubules - physiology Microtubules - ultrastructure Mitochondria Mitochondria - pathology Mitochondria - physiology Molecular Sequence Data Morphology Mutation - genetics Nerve Degeneration - pathology Nerve Degeneration - physiopathology Nervous system Neurons - pathology Neurons - physiology Neurosciences original-paper Pregnancy Proteasome Endopeptidase Complex - physiology Proteins Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Stem Cells Transfection Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Ubiquitin - genetics Ubiquitin - metabolism
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