MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis

MiR-145 can regulate cell apoptosis, proliferation, neural development and stem cell differentiation. Previous studies indicate that miR-145 is downregulated in human colon cancer cells. However, the molecular mechanisms of miR-145 used to regulate colon carcinogenesis and angiogenesis remain to be...

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Veröffentlicht in:	Nucleic acids research 2012-01, Vol.40 (2), p.761-774
Hauptverfasser:	Xu, Qing, Liu, Ling-Zhi, Qian, Xu, Chen, Qi, Jiang, Yue, Li, Dan, Lai, Lihui, Jiang, Bing-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Cell Line, Tumor Cell Proliferation Colonic Neoplasms - blood supply Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Down-Regulation Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Mice, Nude MicroRNAs - metabolism Molecular Biology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Ribosomal Protein S6 Kinases, 70-kDa - genetics Ribosomal Protein S6 Kinases, 70-kDa - metabolism Vascular Endothelial Growth Factor A - metabolism
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