Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque
Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and plaque. These are established measures of subclinical atherosclerosis that predict future...
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| Veröffentlicht in: | Nature genetics 2011-10, Vol.43 (10), p.940-947 |
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| creator | Bis, Joshua C O'Donnell, Christopher J Kavousi, Maryam Franceschini, Nora Isaacs, Aaron Abecasis, Gonçalo R Schminke, Ulf Post, Wendy S Smith, Albert V Cupples, L Adrienne Markus, Hugh S Schmidt, Reinhold Huffman, Jennifer E Lehtimäki, Terho Baumert, Jens Münzel, Thomas Heckbert, Susan R Dehghan, Abbas North, Kari Oostra, Ben Bevan, Steve Stoegerer, Eva-Maria Hayward, Caroline Raitakari, Olli Meisinger, Christa Schillert, Arne Sanna, Serena Völzke, Henry Cheng, Yu-Ching Thorsson, Bolli Fox, Caroline S Rice, Kenneth Rivadeneira, Fernando Nambi, Vijay Halperin, Eran Petrovic, Katja E Peltonen, Leena Wichmann, H Erich Schnabel, Renate B Dörr, Marcus Parsa, Afshin Aspelund, Thor Demissie, Serkalem Kathiresan, Sekar Reilly, Muredach P Taylor, Kent Uitterlinden, Andre Couper, David J Sitzer, Matthias Kähönen, Mika Illig, Thomas Wild, Philipp S Orru, Marco Lüdemann, Jan Shuldiner, Alan R Eiriksdottir, Gudny White, Charles C Rotter, Jerome I Hofman, Albert Seissler, Jochen Zeller, Tanja Usala, Gianluca Ernst, Florian Launer, Lenore J D'Agostino, Ralph B O'Leary, Daniel H Ballantyne, Christie Thiery, Joachim Ziegler, Andreas Lakatta, Edward G Chilukoti, Ravi Kumar Harris, Tamara B Wolf, Philip A Psaty, Bruce M Polak, Joseph F Li, Xia Rathmann, Wolfgang Uda, Manuela Boerwinkle, Eric Klopp, Norman Schmidt, Helena Wilson, James F Viikari, Jorma Koenig, Wolfgang Blankenberg, Stefan Newman, Anne B Witteman, Jacqueline Heiss, Gerardo Duijn, Cornelia van Scuteri, Angelo Homuth, Georg Mitchell, Braxton D Gudnason, Vilmundur |
| description | Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and plaque. These are established measures of subclinical atherosclerosis that predict future cardiovascular disease events.
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (
P
< 5 × 10
−8
). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (
P
< 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events. |
| doi_str_mv | 10.1038/ng.920 |
| format | Article |
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O'Donnell, Christopher J ; Kavousi, Maryam ; Franceschini, Nora ; Isaacs, Aaron ; Abecasis, Gonçalo R ; Schminke, Ulf ; Post, Wendy S ; Smith, Albert V ; Cupples, L Adrienne ; Markus, Hugh S ; Schmidt, Reinhold ; Huffman, Jennifer E ; Lehtimäki, Terho ; Baumert, Jens ; Münzel, Thomas ; Heckbert, Susan R ; Dehghan, Abbas ; North, Kari ; Oostra, Ben ; Bevan, Steve ; Stoegerer, Eva-Maria ; Hayward, Caroline ; Raitakari, Olli ; Meisinger, Christa ; Schillert, Arne ; Sanna, Serena ; Völzke, Henry ; Cheng, Yu-Ching ; Thorsson, Bolli ; Fox, Caroline S ; Rice, Kenneth ; Rivadeneira, Fernando ; Nambi, Vijay ; Halperin, Eran ; Petrovic, Katja E ; Peltonen, Leena ; Wichmann, H Erich ; Schnabel, Renate B ; Dörr, Marcus ; Parsa, Afshin ; Aspelund, Thor ; Demissie, Serkalem ; Kathiresan, Sekar ; Reilly, Muredach P ; Taylor, Kent ; Uitterlinden, Andre ; Couper, David J ; Sitzer, Matthias ; Kähönen, Mika ; Illig, Thomas ; Wild, Philipp S ; Orru, Marco ; Lüdemann, Jan ; Shuldiner, Alan R ; Eiriksdottir, Gudny ; White, Charles C ; Rotter, Jerome I ; Hofman, Albert ; Seissler, Jochen ; Zeller, Tanja ; Usala, Gianluca ; Ernst, Florian ; Launer, Lenore J ; D'Agostino, Ralph B ; O'Leary, Daniel H ; Ballantyne, Christie ; Thiery, Joachim ; Ziegler, Andreas ; Lakatta, Edward G ; Chilukoti, Ravi Kumar ; Harris, Tamara B ; Wolf, Philip A ; Psaty, Bruce M ; Polak, Joseph F ; Li, Xia ; Rathmann, Wolfgang ; Uda, Manuela ; Boerwinkle, Eric ; Klopp, Norman ; Schmidt, Helena ; Wilson, James F ; Viikari, Jorma ; Koenig, Wolfgang ; Blankenberg, Stefan ; Newman, Anne B ; Witteman, Jacqueline ; Heiss, Gerardo ; Duijn, Cornelia van ; Scuteri, Angelo ; Homuth, Georg ; Mitchell, Braxton D ; Gudnason, Vilmundur</creator><creatorcontrib>Bis, Joshua C ; O'Donnell, Christopher J ; Kavousi, Maryam ; Franceschini, Nora ; Isaacs, Aaron ; Abecasis, Gonçalo R ; Schminke, Ulf ; Post, Wendy S ; Smith, Albert V ; Cupples, L Adrienne ; Markus, Hugh S ; Schmidt, Reinhold ; Huffman, Jennifer E ; Lehtimäki, Terho ; Baumert, Jens ; Münzel, Thomas ; Heckbert, Susan R ; Dehghan, Abbas ; North, Kari ; Oostra, Ben ; Bevan, Steve ; Stoegerer, Eva-Maria ; Hayward, Caroline ; Raitakari, Olli ; Meisinger, Christa ; Schillert, Arne ; Sanna, Serena ; Völzke, Henry ; Cheng, Yu-Ching ; Thorsson, Bolli ; Fox, Caroline S ; Rice, Kenneth ; Rivadeneira, Fernando ; Nambi, Vijay ; Halperin, Eran ; Petrovic, Katja E ; Peltonen, Leena ; Wichmann, H Erich ; Schnabel, Renate B ; Dörr, Marcus ; Parsa, Afshin ; Aspelund, Thor ; Demissie, Serkalem ; Kathiresan, Sekar ; Reilly, Muredach P ; Taylor, Kent ; Uitterlinden, Andre ; Couper, David J ; Sitzer, Matthias ; Kähönen, Mika ; Illig, Thomas ; Wild, Philipp S ; Orru, Marco ; Lüdemann, Jan ; Shuldiner, Alan R ; Eiriksdottir, Gudny ; White, Charles C ; Rotter, Jerome I ; Hofman, Albert ; Seissler, Jochen ; Zeller, Tanja ; Usala, Gianluca ; Ernst, Florian ; Launer, Lenore J ; D'Agostino, Ralph B ; O'Leary, Daniel H ; Ballantyne, Christie ; Thiery, Joachim ; Ziegler, Andreas ; Lakatta, Edward G ; Chilukoti, Ravi Kumar ; Harris, Tamara B ; Wolf, Philip A ; Psaty, Bruce M ; Polak, Joseph F ; Li, Xia ; Rathmann, Wolfgang ; Uda, Manuela ; Boerwinkle, Eric ; Klopp, Norman ; Schmidt, Helena ; Wilson, James F ; Viikari, Jorma ; Koenig, Wolfgang ; Blankenberg, Stefan ; Newman, Anne B ; Witteman, Jacqueline ; Heiss, Gerardo ; Duijn, Cornelia van ; Scuteri, Angelo ; Homuth, Georg ; Mitchell, Braxton D ; Gudnason, Vilmundur ; CARDIoGRAM Consortium ; the CARDIoGRAM Consortium</creatorcontrib><description>Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and plaque. These are established measures of subclinical atherosclerosis that predict future cardiovascular disease events.
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (
P
< 5 × 10
−8
). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (
P
< 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng.920</identifier><identifier>PMID: 21909108</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/205/2138 ; 631/208/2489/144 ; 692/308/2779/174 ; 692/699/75/593/2100 ; Adult ; Aged ; Aging - genetics ; Agriculture ; Animal Genetics and Genomics ; Atherosclerosis ; Atherosclerosis - genetics ; Atherosclerosis - physiopathology ; Atherosclerotic plaque ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood pressure ; Cancer Research ; Cardiovascular disease ; Cardiovascular diseases ; Carotid artery diseases ; Carotid Intima-Media Thickness ; Cohort Studies ; Coronary Artery Disease - genetics ; Diagnosis ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Genetic aspects ; Genetic Loci ; Genetic Predisposition to Disease ; Genetics of eukaryotes. Biological and molecular evolution ; Genome, Human ; Genome-Wide Association Study ; Genomes ; Genotype ; Health risk assessment ; Heart - physiopathology ; Human Genetics ; Humans ; Independent study ; Measurement techniques ; Meta-analysis ; Middle Aged ; Phenotype ; Plaque, Atherosclerotic - genetics ; Plaque, Atherosclerotic - pathology ; Polymorphism, Single Nucleotide ; Risk Factors ; Single nucleotide polymorphisms ; Studies ; Veins & arteries ; White People - genetics</subject><ispartof>Nature genetics, 2011-10, Vol.43 (10), p.940-947</ispartof><rights>Springer Nature America, Inc. 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c643t-e4ab59345f3c1c4586056e2a49bc39124f1ae1b950cc7b876cf7d0a171d8778a3</citedby><cites>FETCH-LOGICAL-c643t-e4ab59345f3c1c4586056e2a49bc39124f1ae1b950cc7b876cf7d0a171d8778a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,2729,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24606812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21909108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bis, Joshua C</creatorcontrib><creatorcontrib>O'Donnell, Christopher J</creatorcontrib><creatorcontrib>Kavousi, Maryam</creatorcontrib><creatorcontrib>Franceschini, Nora</creatorcontrib><creatorcontrib>Isaacs, Aaron</creatorcontrib><creatorcontrib>Abecasis, Gonçalo R</creatorcontrib><creatorcontrib>Schminke, Ulf</creatorcontrib><creatorcontrib>Post, Wendy S</creatorcontrib><creatorcontrib>Smith, Albert V</creatorcontrib><creatorcontrib>Cupples, L Adrienne</creatorcontrib><creatorcontrib>Markus, Hugh S</creatorcontrib><creatorcontrib>Schmidt, Reinhold</creatorcontrib><creatorcontrib>Huffman, Jennifer E</creatorcontrib><creatorcontrib>Lehtimäki, Terho</creatorcontrib><creatorcontrib>Baumert, Jens</creatorcontrib><creatorcontrib>Münzel, Thomas</creatorcontrib><creatorcontrib>Heckbert, Susan R</creatorcontrib><creatorcontrib>Dehghan, Abbas</creatorcontrib><creatorcontrib>North, Kari</creatorcontrib><creatorcontrib>Oostra, Ben</creatorcontrib><creatorcontrib>Bevan, Steve</creatorcontrib><creatorcontrib>Stoegerer, Eva-Maria</creatorcontrib><creatorcontrib>Hayward, Caroline</creatorcontrib><creatorcontrib>Raitakari, Olli</creatorcontrib><creatorcontrib>Meisinger, Christa</creatorcontrib><creatorcontrib>Schillert, Arne</creatorcontrib><creatorcontrib>Sanna, Serena</creatorcontrib><creatorcontrib>Völzke, Henry</creatorcontrib><creatorcontrib>Cheng, Yu-Ching</creatorcontrib><creatorcontrib>Thorsson, Bolli</creatorcontrib><creatorcontrib>Fox, Caroline S</creatorcontrib><creatorcontrib>Rice, Kenneth</creatorcontrib><creatorcontrib>Rivadeneira, Fernando</creatorcontrib><creatorcontrib>Nambi, Vijay</creatorcontrib><creatorcontrib>Halperin, Eran</creatorcontrib><creatorcontrib>Petrovic, Katja E</creatorcontrib><creatorcontrib>Peltonen, Leena</creatorcontrib><creatorcontrib>Wichmann, H Erich</creatorcontrib><creatorcontrib>Schnabel, Renate B</creatorcontrib><creatorcontrib>Dörr, Marcus</creatorcontrib><creatorcontrib>Parsa, Afshin</creatorcontrib><creatorcontrib>Aspelund, Thor</creatorcontrib><creatorcontrib>Demissie, Serkalem</creatorcontrib><creatorcontrib>Kathiresan, Sekar</creatorcontrib><creatorcontrib>Reilly, Muredach P</creatorcontrib><creatorcontrib>Taylor, Kent</creatorcontrib><creatorcontrib>Uitterlinden, Andre</creatorcontrib><creatorcontrib>Couper, David J</creatorcontrib><creatorcontrib>Sitzer, Matthias</creatorcontrib><creatorcontrib>Kähönen, Mika</creatorcontrib><creatorcontrib>Illig, Thomas</creatorcontrib><creatorcontrib>Wild, Philipp S</creatorcontrib><creatorcontrib>Orru, Marco</creatorcontrib><creatorcontrib>Lüdemann, Jan</creatorcontrib><creatorcontrib>Shuldiner, Alan R</creatorcontrib><creatorcontrib>Eiriksdottir, Gudny</creatorcontrib><creatorcontrib>White, Charles C</creatorcontrib><creatorcontrib>Rotter, Jerome I</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Seissler, Jochen</creatorcontrib><creatorcontrib>Zeller, Tanja</creatorcontrib><creatorcontrib>Usala, Gianluca</creatorcontrib><creatorcontrib>Ernst, Florian</creatorcontrib><creatorcontrib>Launer, Lenore J</creatorcontrib><creatorcontrib>D'Agostino, Ralph B</creatorcontrib><creatorcontrib>O'Leary, Daniel H</creatorcontrib><creatorcontrib>Ballantyne, Christie</creatorcontrib><creatorcontrib>Thiery, Joachim</creatorcontrib><creatorcontrib>Ziegler, Andreas</creatorcontrib><creatorcontrib>Lakatta, Edward G</creatorcontrib><creatorcontrib>Chilukoti, Ravi Kumar</creatorcontrib><creatorcontrib>Harris, Tamara B</creatorcontrib><creatorcontrib>Wolf, Philip A</creatorcontrib><creatorcontrib>Psaty, Bruce M</creatorcontrib><creatorcontrib>Polak, Joseph F</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Rathmann, Wolfgang</creatorcontrib><creatorcontrib>Uda, Manuela</creatorcontrib><creatorcontrib>Boerwinkle, Eric</creatorcontrib><creatorcontrib>Klopp, Norman</creatorcontrib><creatorcontrib>Schmidt, Helena</creatorcontrib><creatorcontrib>Wilson, James F</creatorcontrib><creatorcontrib>Viikari, Jorma</creatorcontrib><creatorcontrib>Koenig, Wolfgang</creatorcontrib><creatorcontrib>Blankenberg, Stefan</creatorcontrib><creatorcontrib>Newman, Anne B</creatorcontrib><creatorcontrib>Witteman, Jacqueline</creatorcontrib><creatorcontrib>Heiss, Gerardo</creatorcontrib><creatorcontrib>Duijn, Cornelia van</creatorcontrib><creatorcontrib>Scuteri, Angelo</creatorcontrib><creatorcontrib>Homuth, Georg</creatorcontrib><creatorcontrib>Mitchell, Braxton D</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>CARDIoGRAM Consortium</creatorcontrib><creatorcontrib>the CARDIoGRAM Consortium</creatorcontrib><title>Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and plaque. These are established measures of subclinical atherosclerosis that predict future cardiovascular disease events.
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (
P
< 5 × 10
−8
). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (
P
< 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.</description><subject>631/208/205/2138</subject><subject>631/208/2489/144</subject><subject>692/308/2779/174</subject><subject>692/699/75/593/2100</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging - genetics</subject><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - genetics</subject><subject>Atherosclerosis - physiopathology</subject><subject>Atherosclerotic plaque</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood pressure</subject><subject>Cancer Research</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Carotid artery diseases</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cohort Studies</subject><subject>Coronary Artery Disease - genetics</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic Loci</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome, Human</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Health risk assessment</subject><subject>Heart - physiopathology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Independent study</subject><subject>Measurement techniques</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Plaque, Atherosclerotic - genetics</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Studies</subject><subject>Veins & arteries</subject><subject>White People - 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of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque</title><author>Bis, Joshua C ; O'Donnell, Christopher J ; Kavousi, Maryam ; Franceschini, Nora ; Isaacs, Aaron ; Abecasis, Gonçalo R ; Schminke, Ulf ; Post, Wendy S ; Smith, Albert V ; Cupples, L Adrienne ; Markus, Hugh S ; Schmidt, Reinhold ; Huffman, Jennifer E ; Lehtimäki, Terho ; Baumert, Jens ; Münzel, Thomas ; Heckbert, Susan R ; Dehghan, Abbas ; North, Kari ; Oostra, Ben ; Bevan, Steve ; Stoegerer, Eva-Maria ; Hayward, Caroline ; Raitakari, Olli ; Meisinger, Christa ; Schillert, Arne ; Sanna, Serena ; Völzke, Henry ; Cheng, Yu-Ching ; Thorsson, Bolli ; Fox, Caroline S ; Rice, Kenneth ; Rivadeneira, Fernando ; Nambi, Vijay ; Halperin, Eran ; Petrovic, Katja E ; Peltonen, Leena ; Wichmann, H Erich ; Schnabel, Renate B ; Dörr, Marcus ; Parsa, Afshin ; Aspelund, Thor ; Demissie, Serkalem ; Kathiresan, Sekar ; Reilly, Muredach P ; Taylor, Kent ; Uitterlinden, Andre ; Couper, David J ; Sitzer, Matthias ; Kähönen, Mika ; Illig, Thomas ; Wild, Philipp S ; Orru, Marco ; Lüdemann, Jan ; Shuldiner, Alan R ; Eiriksdottir, Gudny ; White, Charles C ; Rotter, Jerome I ; Hofman, Albert ; Seissler, Jochen ; Zeller, Tanja ; Usala, Gianluca ; Ernst, Florian ; Launer, Lenore J ; D'Agostino, Ralph B ; O'Leary, Daniel H ; Ballantyne, Christie ; Thiery, Joachim ; Ziegler, Andreas ; Lakatta, Edward G ; Chilukoti, Ravi Kumar ; Harris, Tamara B ; Wolf, Philip A ; Psaty, Bruce M ; Polak, Joseph F ; Li, Xia ; Rathmann, Wolfgang ; Uda, Manuela ; Boerwinkle, Eric ; Klopp, Norman ; Schmidt, Helena ; Wilson, James F ; Viikari, Jorma ; Koenig, Wolfgang ; Blankenberg, Stefan ; Newman, Anne B ; Witteman, Jacqueline ; Heiss, Gerardo ; Duijn, Cornelia van ; Scuteri, Angelo ; Homuth, Georg ; Mitchell, Braxton D ; Gudnason, Vilmundur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c643t-e4ab59345f3c1c4586056e2a49bc39124f1ae1b950cc7b876cf7d0a171d8778a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/205/2138</topic><topic>631/208/2489/144</topic><topic>692/308/2779/174</topic><topic>692/699/75/593/2100</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging - genetics</topic><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - genetics</topic><topic>Atherosclerosis - physiopathology</topic><topic>Atherosclerotic plaque</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood pressure</topic><topic>Cancer Research</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Carotid artery diseases</topic><topic>Carotid Intima-Media Thickness</topic><topic>Cohort Studies</topic><topic>Coronary Artery Disease - genetics</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Function</topic><topic>Genetic aspects</topic><topic>Genetic Loci</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genome, Human</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Health risk assessment</topic><topic>Heart - physiopathology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Independent study</topic><topic>Measurement techniques</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Phenotype</topic><topic>Plaque, Atherosclerotic - genetics</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Studies</topic><topic>Veins & arteries</topic><topic>White People - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bis, Joshua C</creatorcontrib><creatorcontrib>O'Donnell, Christopher J</creatorcontrib><creatorcontrib>Kavousi, Maryam</creatorcontrib><creatorcontrib>Franceschini, 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Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bis, Joshua C</au><au>O'Donnell, Christopher J</au><au>Kavousi, Maryam</au><au>Franceschini, Nora</au><au>Isaacs, Aaron</au><au>Abecasis, Gonçalo R</au><au>Schminke, Ulf</au><au>Post, Wendy S</au><au>Smith, Albert V</au><au>Cupples, L Adrienne</au><au>Markus, Hugh S</au><au>Schmidt, Reinhold</au><au>Huffman, Jennifer E</au><au>Lehtimäki, Terho</au><au>Baumert, Jens</au><au>Münzel, Thomas</au><au>Heckbert, Susan R</au><au>Dehghan, Abbas</au><au>North, Kari</au><au>Oostra, Ben</au><au>Bevan, Steve</au><au>Stoegerer, Eva-Maria</au><au>Hayward, Caroline</au><au>Raitakari, Olli</au><au>Meisinger, Christa</au><au>Schillert, Arne</au><au>Sanna, Serena</au><au>Völzke, Henry</au><au>Cheng, Yu-Ching</au><au>Thorsson, Bolli</au><au>Fox, Caroline S</au><au>Rice, Kenneth</au><au>Rivadeneira, Fernando</au><au>Nambi, Vijay</au><au>Halperin, Eran</au><au>Petrovic, Katja E</au><au>Peltonen, Leena</au><au>Wichmann, H Erich</au><au>Schnabel, Renate B</au><au>Dörr, Marcus</au><au>Parsa, Afshin</au><au>Aspelund, Thor</au><au>Demissie, Serkalem</au><au>Kathiresan, Sekar</au><au>Reilly, Muredach P</au><au>Taylor, Kent</au><au>Uitterlinden, Andre</au><au>Couper, David J</au><au>Sitzer, Matthias</au><au>Kähönen, Mika</au><au>Illig, Thomas</au><au>Wild, Philipp S</au><au>Orru, Marco</au><au>Lüdemann, Jan</au><au>Shuldiner, Alan R</au><au>Eiriksdottir, Gudny</au><au>White, Charles C</au><au>Rotter, Jerome I</au><au>Hofman, Albert</au><au>Seissler, Jochen</au><au>Zeller, Tanja</au><au>Usala, Gianluca</au><au>Ernst, Florian</au><au>Launer, Lenore J</au><au>D'Agostino, Ralph B</au><au>O'Leary, Daniel H</au><au>Ballantyne, Christie</au><au>Thiery, Joachim</au><au>Ziegler, Andreas</au><au>Lakatta, Edward G</au><au>Chilukoti, Ravi Kumar</au><au>Harris, Tamara B</au><au>Wolf, Philip A</au><au>Psaty, Bruce M</au><au>Polak, Joseph F</au><au>Li, Xia</au><au>Rathmann, Wolfgang</au><au>Uda, Manuela</au><au>Boerwinkle, Eric</au><au>Klopp, Norman</au><au>Schmidt, Helena</au><au>Wilson, James F</au><au>Viikari, Jorma</au><au>Koenig, Wolfgang</au><au>Blankenberg, Stefan</au><au>Newman, Anne B</au><au>Witteman, Jacqueline</au><au>Heiss, Gerardo</au><au>Duijn, Cornelia van</au><au>Scuteri, Angelo</au><au>Homuth, Georg</au><au>Mitchell, Braxton D</au><au>Gudnason, Vilmundur</au><aucorp>CARDIoGRAM Consortium</aucorp><aucorp>the CARDIoGRAM Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>43</volume><issue>10</issue><spage>940</spage><epage>947</epage><pages>940-947</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and plaque. These are established measures of subclinical atherosclerosis that predict future cardiovascular disease events.
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (
P
< 5 × 10
−8
). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (
P
< 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>21909108</pmid><doi>10.1038/ng.920</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 2011-10, Vol.43 (10), p.940-947 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3257519 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | 631/208/205/2138 631/208/2489/144 692/308/2779/174 692/699/75/593/2100 Adult Aged Aging - genetics Agriculture Animal Genetics and Genomics Atherosclerosis Atherosclerosis - genetics Atherosclerosis - physiopathology Atherosclerotic plaque Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood pressure Cancer Research Cardiovascular disease Cardiovascular diseases Carotid artery diseases Carotid Intima-Media Thickness Cohort Studies Coronary Artery Disease - genetics Diagnosis Epidemiology Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic Loci Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genome-Wide Association Study Genomes Genotype Health risk assessment Heart - physiopathology Human Genetics Humans Independent study Measurement techniques Meta-analysis Middle Aged Phenotype Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - pathology Polymorphism, Single Nucleotide Risk Factors Single nucleotide polymorphisms Studies Veins & arteries White People - genetics |
| title | Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque |
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