Genetic analysis of Down syndrome-associated heart defects in mice

Human trisomy 21, the chromosomal basis of Down syndrome (DS), is the most common genetic cause of heart defects. Regions on human chromosome 21 (Hsa21) are syntenically conserved with three regions located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. In this study, we have analyzed the impact o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human genetics 2011-11, Vol.130 (5), p.623-632
Hauptverfasser:	Liu, Chunhong, Morishima, Masae, Yu, Tao, Matsui, Sei-Ichi, Zhang, Li, Fu, Dawei, Pao, Annie, Costa, Alberto C., Gardiner, Katheleen J., Cowell, John K., Nowak, Normal J., Parmacek, Michael S., Liang, Ping, Baldini, Antonio, Yu, Y. Eugene
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cardiovascular disease chromosome 10 chromosome 21 Chromosome aberrations Chromosome deletion Chromosomes Classical genetics, quantitative genetics, hybrids Congenital diseases Disease Models, Animal Down syndrome Down Syndrome - genetics Down's syndrome Embryos Female Fundamental and applied biological sciences. Psychology G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics Gene Duplication - genetics Gene Function Genetic analysis Genetic aspects Genetics of eukaryotes. Biological and molecular evolution genomics Guanine Nucleotide Exchange Factors - genetics Heart Heart Defects, Congenital - genetics Human Human Genetics Male Medical genetics Medical sciences Metabolic Diseases Mice Mice, Mutant Strains Molecular Medicine Original Investigation Sequence Deletion - genetics Synteny Synteny - genetics T-Lymphoma Invasion and Metastasis-inducing Protein 1 Tiam1 protein Transcription Trisomy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!