Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells

Naive antiviral CD8(+) T cells are activated in the draining LN (DLN) by dendritic cells (DCs) presenting viral antigens. However, many viruses infect LN macrophages, which participate in initiation of innate immunity and B cell activation. To better understand how and why T cells select infected DC...

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Veröffentlicht in:	The Journal of experimental medicine 2011-11, Vol.208 (12), p.2511-2524
Hauptverfasser:	Hickman, Heather D, Li, Lily, Reynoso, Glennys V, Rubin, Erica J, Skon, Cara N, Mays, Jacqueline W, Gibbs, James, Schwartz, Owen, Bennink, Jack R, Yewdell, Jonathan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antigens, Viral - immunology CD8-Positive T-Lymphocytes - immunology Chemokines - immunology Chemokines - metabolism Dendritic Cells - immunology Dendritic Cells - virology Histocytochemistry Lymph Nodes - cytology Lymph Nodes - immunology Lymphocyte Activation - immunology Macrophages - virology Mice Mice, Transgenic Microscopy, Confocal Receptors, CCR5 - metabolism Vaccinia virus Vaccinia virus - immunology
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