Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin

FOXO3a is a forkhead transcription factor that regulates a multitude of important cellular processes, including proliferation, apoptosis, differentiation, and metabolism. Doxorubicin treatment of MCF-7 breast carcinoma cells results in FOXO3a nuclear relocation and the induction of the stress-activa...

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Veröffentlicht in:	The Journal of biological chemistry 2012-01, Vol.287 (2), p.1545-1555
Hauptverfasser:	Ho, Ka-Kei, McGuire, Victoria A., Koo, Chuay-Yeng, Muir, Kyle W., de Olano, Natalia, Maifoshie, Evie, Kelly, Douglas J., McGovern, Ursula B., Monteiro, Lara J., Gomes, Ana R., Nebreda, Angel R., Campbell, David G., Arthur, J. Simon C., Lam, Eric W.-F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Active Transport, Cell Nucleus - genetics Amino Acid Substitution Animals Antibiotics, Antineoplastic - pharmacology Breast Cancer Cancer Therapy Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism Doxorubicin - pharmacology Enzyme Inhibitors - pharmacology Forkhead Box Protein O3 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism HEK293 Cells Humans Imidazoles - pharmacology Mice Mice, Knockout Molecular Bases of Disease Mutation, Missense Nuclear Translocation p38 MAPK p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Phosphorylation - genetics Pyridines - pharmacology Signal Transduction Transcription Factors
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