CENP-E Kinesin Interacts with SKAP Protein to Orchestrate Accurate Chromosome Segregation in Mitosis

Mitotic chromosome segregation is orchestrated by the dynamic interaction of spindle microtubules with the kinetochore. Although previous studies show that the mitotic kinesin CENP-E forms a link between attachment of the spindle microtubule to the kinetochore and the mitotic checkpoint signaling ca...

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Veröffentlicht in:	The Journal of biological chemistry 2012-01, Vol.287 (2), p.1500-1509
Hauptverfasser:	Huang, Yuejia, Wang, Wenwen, Yao, Phil, Wang, Xiwei, Liu, Xing, Zhuang, Xiaoxuan, Yan, Feng, Zhou, Jinhua, Du, Jian, Ward, Tarsha, Zou, Hanfa, Zhang, Jiancun, Fang, Guowei, Ding, Xia, Dou, Zhen, Yao, Xuebiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism CENP-E Centromeres Checkpoint Control Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosome Alignment Chromosome Dynamics Chromosome Segregation - physiology Chromosomes, Human - genetics Chromosomes, Human - metabolism HeLa Cells Humans Kinesin - genetics Kinesin - metabolism Kinetochore Kinetochores - metabolism Mass Spectrometry (MS) Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules - genetics Microtubules - metabolism Mitosis - physiology SKAP Spindle Apparatus - genetics Spindle Apparatus - metabolism Syntelin Tubulin
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