Human rhinoviruses in severe respiratory disease in very low birth weight infants
To assess incidence, burden of illness, and risk factors for human rhinoviruses (HRVs) in a cohort of very low birth weight (VLBW) infants. A 2-year prospective cohort study was conducted among VLBW premature infants in Buenos Aires, Argentina. Infants were enrolled in the NICU from June 1, 2003, to...
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| Veröffentlicht in: | Pediatrics (Evanston) 2012-01, Vol.129 (1), p.e60-e67 |
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| creator | Miller, E Kathryn Bugna, Jimena Libster, Romina Shepherd, Bryan E Scalzo, Paula M Acosta, Patricio L Hijano, Diego Reynoso, Natalia Batalle, Juan P Coviello, Silvina Klein, M Ines Bauer, Gabriela Benitez, Alicia Kleeberger, Steven R Polack, Fernando P |
| description | To assess incidence, burden of illness, and risk factors for human rhinoviruses (HRVs) in a cohort of very low birth weight (VLBW) infants.
A 2-year prospective cohort study was conducted among VLBW premature infants in Buenos Aires, Argentina. Infants were enrolled in the NICU from June 1, 2003, to May 31, 2005, and managed monthly and with every acute respiratory illness (ARI) during the first year of life. Nasal wash samples were obtained during every respiratory episode and tested for HRV, respiratory syncytial virus (RSV), human parainfluenza viruses, influenza viruses, and human metapneumovirus using reverse transcriptase-polymerase chain reaction.
Of 119 patients, 66 (55%) had HRV-associated ARIs. The incidence of HRV-associated ARI was 123 events per 100 child-years of follow-up. Of those infants experiencing an episode of bronchiolitis, 40% had HRV versus 7% with RSV. The incidence of HRV-associated bronchiolitis was 75 per 100 infant-years of follow-up. HRV was associated with 12 of 36 hospitalizations (33%), and RSV was associated with 9 of 36 hospitalizations (25%). The incidence of HRV-associated hospitalization was 12 per 100 infant-years of follow-up. The risk of HRV-associated hospitalization was higher for infants with bronchopulmonary dysplasia and those who were not breastfed.
HRV is an important and frequent pathogen associated with severe respiratory infections in VLBW infants. Bronchopulmonary dysplasia and the absence of breastfeeding are risk factors for hospitalization. The results of our study reveal that HRV is the predominant pathogen of respiratory infections in premature infants. |
| doi_str_mv | 10.1542/peds.2011-0583 |
| format | Article |
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A 2-year prospective cohort study was conducted among VLBW premature infants in Buenos Aires, Argentina. Infants were enrolled in the NICU from June 1, 2003, to May 31, 2005, and managed monthly and with every acute respiratory illness (ARI) during the first year of life. Nasal wash samples were obtained during every respiratory episode and tested for HRV, respiratory syncytial virus (RSV), human parainfluenza viruses, influenza viruses, and human metapneumovirus using reverse transcriptase-polymerase chain reaction.
Of 119 patients, 66 (55%) had HRV-associated ARIs. The incidence of HRV-associated ARI was 123 events per 100 child-years of follow-up. Of those infants experiencing an episode of bronchiolitis, 40% had HRV versus 7% with RSV. The incidence of HRV-associated bronchiolitis was 75 per 100 infant-years of follow-up. HRV was associated with 12 of 36 hospitalizations (33%), and RSV was associated with 9 of 36 hospitalizations (25%). The incidence of HRV-associated hospitalization was 12 per 100 infant-years of follow-up. The risk of HRV-associated hospitalization was higher for infants with bronchopulmonary dysplasia and those who were not breastfed.
HRV is an important and frequent pathogen associated with severe respiratory infections in VLBW infants. Bronchopulmonary dysplasia and the absence of breastfeeding are risk factors for hospitalization. The results of our study reveal that HRV is the predominant pathogen of respiratory infections in premature infants.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2011-0583</identifier><identifier>PMID: 22201153</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Acute Disease ; Babies ; Birth weight ; Bronchiolitis, Viral - virology ; Causes of ; Childrens health ; Cohort Studies ; Control ; Health aspects ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - virology ; Infant, Very Low Birth Weight ; Infants (Newborn) ; Newborn infants ; Pediatrics ; Respiratory diseases ; Respiratory Syncytial Viruses - isolation & purification ; Respiratory Tract Infections - virology ; Reverse Transcriptase Polymerase Chain Reaction ; Rhinovirus - isolation & purification ; Rhinoviruses ; Severe acute respiratory syndrome ; Viruses</subject><ispartof>Pediatrics (Evanston), 2012-01, Vol.129 (1), p.e60-e67</ispartof><rights>Copyright American Academy of Pediatrics Jan 2012</rights><rights>Copyright © 2012 by the American Academy of Pediatrics 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-843d697690766788e41fa8fa2522a89e2475975a3a597d512cfcffc146eaf01f3</citedby><cites>FETCH-LOGICAL-c454t-843d697690766788e41fa8fa2522a89e2475975a3a597d512cfcffc146eaf01f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22201153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, E Kathryn</creatorcontrib><creatorcontrib>Bugna, Jimena</creatorcontrib><creatorcontrib>Libster, Romina</creatorcontrib><creatorcontrib>Shepherd, Bryan E</creatorcontrib><creatorcontrib>Scalzo, Paula M</creatorcontrib><creatorcontrib>Acosta, Patricio L</creatorcontrib><creatorcontrib>Hijano, Diego</creatorcontrib><creatorcontrib>Reynoso, Natalia</creatorcontrib><creatorcontrib>Batalle, Juan P</creatorcontrib><creatorcontrib>Coviello, Silvina</creatorcontrib><creatorcontrib>Klein, M Ines</creatorcontrib><creatorcontrib>Bauer, Gabriela</creatorcontrib><creatorcontrib>Benitez, Alicia</creatorcontrib><creatorcontrib>Kleeberger, Steven R</creatorcontrib><creatorcontrib>Polack, Fernando P</creatorcontrib><title>Human rhinoviruses in severe respiratory disease in very low birth weight infants</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>To assess incidence, burden of illness, and risk factors for human rhinoviruses (HRVs) in a cohort of very low birth weight (VLBW) infants.
A 2-year prospective cohort study was conducted among VLBW premature infants in Buenos Aires, Argentina. Infants were enrolled in the NICU from June 1, 2003, to May 31, 2005, and managed monthly and with every acute respiratory illness (ARI) during the first year of life. Nasal wash samples were obtained during every respiratory episode and tested for HRV, respiratory syncytial virus (RSV), human parainfluenza viruses, influenza viruses, and human metapneumovirus using reverse transcriptase-polymerase chain reaction.
Of 119 patients, 66 (55%) had HRV-associated ARIs. The incidence of HRV-associated ARI was 123 events per 100 child-years of follow-up. Of those infants experiencing an episode of bronchiolitis, 40% had HRV versus 7% with RSV. The incidence of HRV-associated bronchiolitis was 75 per 100 infant-years of follow-up. HRV was associated with 12 of 36 hospitalizations (33%), and RSV was associated with 9 of 36 hospitalizations (25%). The incidence of HRV-associated hospitalization was 12 per 100 infant-years of follow-up. The risk of HRV-associated hospitalization was higher for infants with bronchopulmonary dysplasia and those who were not breastfed.
HRV is an important and frequent pathogen associated with severe respiratory infections in VLBW infants. Bronchopulmonary dysplasia and the absence of breastfeeding are risk factors for hospitalization. The results of our study reveal that HRV is the predominant pathogen of respiratory infections in premature infants.</description><subject>Acute Disease</subject><subject>Babies</subject><subject>Birth weight</subject><subject>Bronchiolitis, Viral - virology</subject><subject>Causes of</subject><subject>Childrens health</subject><subject>Cohort Studies</subject><subject>Control</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - virology</subject><subject>Infant, Very Low Birth Weight</subject><subject>Infants (Newborn)</subject><subject>Newborn infants</subject><subject>Pediatrics</subject><subject>Respiratory diseases</subject><subject>Respiratory Syncytial Viruses - isolation & purification</subject><subject>Respiratory Tract Infections - virology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Rhinovirus - isolation & purification</subject><subject>Rhinoviruses</subject><subject>Severe acute respiratory syndrome</subject><subject>Viruses</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1PGzEUxK2qqKRprz1Wq144bfDn7vqChCJakJAQUnu2jPc5MdrYwfYG8t_XqwACTnOY3xu90SD0g-AFEZyebqFPC4oJqbHo2Cc0I1h2Naet-IxmGDNSc4zFMfqa0j3GmIuWfkHHlE4ngs3Q7eW40b6Ka-fDzsUxQaqcrxLsIEIVIW1d1DnEfdW7BDrB5BZvXw3hsbpzMa-rR3CrdS6G1T6nb-jI6iHB92edo3-_L_4uL-vrmz9Xy_Pr2nDBc91x1jeybSRum6btOuDE6s5qKijVnQTKWyFboZku0gtCjTXWGsIb0BYTy-bo7JC7He820BvwOepBbaPb6LhXQTv13vFurVZhpxgVgjeiBJw8B8TwMELKauOSgWHQHsKYlCSMc0aLzNGvD-R9GKMv7QpUEMElK1B9gFZ6AOW8CT7DUzZhGGAFqnRf3qhz2sqOljay8IsDb2JIKYJ9fZ1gNW2rpm3VNJSati0HP98WfsVfxmT_AQFcoA0</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Miller, E Kathryn</creator><creator>Bugna, Jimena</creator><creator>Libster, Romina</creator><creator>Shepherd, Bryan E</creator><creator>Scalzo, Paula M</creator><creator>Acosta, Patricio L</creator><creator>Hijano, Diego</creator><creator>Reynoso, Natalia</creator><creator>Batalle, Juan P</creator><creator>Coviello, Silvina</creator><creator>Klein, M Ines</creator><creator>Bauer, Gabriela</creator><creator>Benitez, Alicia</creator><creator>Kleeberger, Steven R</creator><creator>Polack, Fernando P</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201201</creationdate><title>Human rhinoviruses in severe respiratory disease in very low birth weight infants</title><author>Miller, E Kathryn ; Bugna, Jimena ; Libster, Romina ; Shepherd, Bryan E ; Scalzo, Paula M ; Acosta, Patricio L ; Hijano, Diego ; Reynoso, Natalia ; Batalle, Juan P ; Coviello, Silvina ; Klein, M Ines ; Bauer, Gabriela ; Benitez, Alicia ; Kleeberger, Steven R ; Polack, Fernando P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-843d697690766788e41fa8fa2522a89e2475975a3a597d512cfcffc146eaf01f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Disease</topic><topic>Babies</topic><topic>Birth weight</topic><topic>Bronchiolitis, Viral - virology</topic><topic>Causes of</topic><topic>Childrens health</topic><topic>Cohort Studies</topic><topic>Control</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - virology</topic><topic>Infant, Very Low Birth Weight</topic><topic>Infants (Newborn)</topic><topic>Newborn infants</topic><topic>Pediatrics</topic><topic>Respiratory diseases</topic><topic>Respiratory Syncytial Viruses - isolation & purification</topic><topic>Respiratory Tract Infections - virology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Rhinovirus - isolation & purification</topic><topic>Rhinoviruses</topic><topic>Severe acute respiratory syndrome</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, E Kathryn</creatorcontrib><creatorcontrib>Bugna, Jimena</creatorcontrib><creatorcontrib>Libster, Romina</creatorcontrib><creatorcontrib>Shepherd, Bryan E</creatorcontrib><creatorcontrib>Scalzo, Paula M</creatorcontrib><creatorcontrib>Acosta, Patricio L</creatorcontrib><creatorcontrib>Hijano, Diego</creatorcontrib><creatorcontrib>Reynoso, Natalia</creatorcontrib><creatorcontrib>Batalle, Juan P</creatorcontrib><creatorcontrib>Coviello, Silvina</creatorcontrib><creatorcontrib>Klein, M Ines</creatorcontrib><creatorcontrib>Bauer, Gabriela</creatorcontrib><creatorcontrib>Benitez, Alicia</creatorcontrib><creatorcontrib>Kleeberger, Steven R</creatorcontrib><creatorcontrib>Polack, Fernando P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, E Kathryn</au><au>Bugna, Jimena</au><au>Libster, Romina</au><au>Shepherd, Bryan E</au><au>Scalzo, Paula M</au><au>Acosta, Patricio L</au><au>Hijano, Diego</au><au>Reynoso, Natalia</au><au>Batalle, Juan P</au><au>Coviello, Silvina</au><au>Klein, M Ines</au><au>Bauer, Gabriela</au><au>Benitez, Alicia</au><au>Kleeberger, Steven R</au><au>Polack, Fernando P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human rhinoviruses in severe respiratory disease in very low birth weight infants</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2012-01</date><risdate>2012</risdate><volume>129</volume><issue>1</issue><spage>e60</spage><epage>e67</epage><pages>e60-e67</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>To assess incidence, burden of illness, and risk factors for human rhinoviruses (HRVs) in a cohort of very low birth weight (VLBW) infants.
A 2-year prospective cohort study was conducted among VLBW premature infants in Buenos Aires, Argentina. Infants were enrolled in the NICU from June 1, 2003, to May 31, 2005, and managed monthly and with every acute respiratory illness (ARI) during the first year of life. Nasal wash samples were obtained during every respiratory episode and tested for HRV, respiratory syncytial virus (RSV), human parainfluenza viruses, influenza viruses, and human metapneumovirus using reverse transcriptase-polymerase chain reaction.
Of 119 patients, 66 (55%) had HRV-associated ARIs. The incidence of HRV-associated ARI was 123 events per 100 child-years of follow-up. Of those infants experiencing an episode of bronchiolitis, 40% had HRV versus 7% with RSV. The incidence of HRV-associated bronchiolitis was 75 per 100 infant-years of follow-up. HRV was associated with 12 of 36 hospitalizations (33%), and RSV was associated with 9 of 36 hospitalizations (25%). The incidence of HRV-associated hospitalization was 12 per 100 infant-years of follow-up. The risk of HRV-associated hospitalization was higher for infants with bronchopulmonary dysplasia and those who were not breastfed.
HRV is an important and frequent pathogen associated with severe respiratory infections in VLBW infants. Bronchopulmonary dysplasia and the absence of breastfeeding are risk factors for hospitalization. The results of our study reveal that HRV is the predominant pathogen of respiratory infections in premature infants.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>22201153</pmid><doi>10.1542/peds.2011-0583</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Babies Birth weight Bronchiolitis, Viral - virology Causes of Childrens health Cohort Studies Control Health aspects Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases - virology Infant, Very Low Birth Weight Infants (Newborn) Newborn infants Pediatrics Respiratory diseases Respiratory Syncytial Viruses - isolation & purification Respiratory Tract Infections - virology Reverse Transcriptase Polymerase Chain Reaction Rhinovirus - isolation & purification Rhinoviruses Severe acute respiratory syndrome Viruses |
| title | Human rhinoviruses in severe respiratory disease in very low birth weight infants |
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