Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia

Abstract The functional integrity of the dorsolateral prefrontal cortex (DLPFC) is altered in schizophrenia leading to profound deficits in working memory and cognition. Growing evidence indicates that dysregulation of glutamate signaling may be a significant contributor to the pathophysiology media...

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Veröffentlicht in:	Schizophrenia research 2007-12, Vol.97 (1), p.277-288
Hauptverfasser:	O'Connor, J.A, Hemby, S.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies AMPA Biological and medical sciences Bipolar Disorder - genetics Bipolar Disorder - pathology Carrier Proteins - genetics Depressive Disorder, Major - genetics Depressive Disorder, Major - pathology Dorsolateral prefrontal cortex Female Humans Laser capture microdissection Male Medical sciences Microdissection Middle Aged Nerve Tissue Proteins - genetics NMDA Polymerase Chain Reaction Prefrontal Cortex - pathology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Pyramidal cell Pyramidal Cells - pathology Quantitative PCR Receptors, AMPA - genetics Receptors, N-Methyl-D-Aspartate - genetics Reference Values RNA, Messenger - genetics Schizophrenia Schizophrenia - genetics Schizophrenia - pathology
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