γ-Secretase inhibitors and modulators for Alzheimer's disease

J. Neurochem. (2012) 120 (Suppl. 1), 89–98. γ‐Secretase is a membrane embedded aspartyl protease complex with presenilin as the catalytic component. Along with β‐secretase, this enzyme produces the amyloid β‐protein of Alzheimer’s disease (AD) from the amyloid β‐protein precursor. Because of its key...

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Veröffentlicht in:	Journal of neurochemistry 2012-01, Vol.120 (s1), p.89-98
1. Verfasser:	Wolfe, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	active site allosteric sites Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - metabolism Alzheimer's disease amyloid Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - physiology Animals Aspartic endopeptidase chemical probes Chronic exposure docking site Humans Inhibitors Modulators Neurodegenerative diseases Neuromodulation Pathogenesis Peptides Precursors Presenilin Protease Protease inhibitors Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Proteinase Proteinase inhibitors Proteins Proteolysis Receptors, Notch - chemistry Receptors, Notch - physiology Secretase Signal transduction Signal Transduction - drug effects Signal Transduction - physiology
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