Delivery by Cesarean Section and Early Childhood Respiratory Symptoms and Disorders: The Norwegian Mother and Child Cohort Study
Studies have indicated that children delivered by cesarean section are at an increased risk of developing wheezing and asthma. This could be the result of an altered immune system development due to delayed gut colonization or of increased neonatal respiratory morbidity. The authors examined the ass...
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| Veröffentlicht in: | American journal of epidemiology 2011-12, Vol.174 (11), p.1275-1285 |
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| creator | MAGNUS, Maria C HABERG, Siri E STIGUM, Hein NAFSTAD, Per LONDON, Stephanie J VANGEN, Siri NYSTAD, Wenche |
| description | Studies have indicated that children delivered by cesarean section are at an increased risk of developing wheezing and asthma. This could be the result of an altered immune system development due to delayed gut colonization or of increased neonatal respiratory morbidity. The authors examined the associations between delivery by cesarean section and the development of wheezing, asthma, and recurrent lower respiratory tract infections in children up to 36 months of age among 37,171 children in the Norwegian Mother and Child Cohort Study. Generalized linear models were used in the multivariable analysis. Children delivered by cesarean section had an increased likelihood of current asthma at 36 months of age (relative risk = 1.17, 95% confidence interval: 1.03, 1.32), and the association was stronger among children of nonatopic mothers (relative risk = 1.33, 95% confidence interval: 1.12, 1.58). No increased risk of wheezing or recurrent lower respiratory tract infections was seen among children delivered by cesarean section. Findings were similar among children delivered by acute and elective cesarean section. In conclusion, children delivered by cesarean section may have an increased risk of current asthma at 36 months, but residual confounding cannot be excluded. In future prospective studies, investigators should reexamine this association in different age groups. |
| doi_str_mv | 10.1093/aje/kwr242 |
| format | Article |
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This could be the result of an altered immune system development due to delayed gut colonization or of increased neonatal respiratory morbidity. The authors examined the associations between delivery by cesarean section and the development of wheezing, asthma, and recurrent lower respiratory tract infections in children up to 36 months of age among 37,171 children in the Norwegian Mother and Child Cohort Study. Generalized linear models were used in the multivariable analysis. Children delivered by cesarean section had an increased likelihood of current asthma at 36 months of age (relative risk = 1.17, 95% confidence interval: 1.03, 1.32), and the association was stronger among children of nonatopic mothers (relative risk = 1.33, 95% confidence interval: 1.12, 1.58). No increased risk of wheezing or recurrent lower respiratory tract infections was seen among children delivered by cesarean section. Findings were similar among children delivered by acute and elective cesarean section. In conclusion, children delivered by cesarean section may have an increased risk of current asthma at 36 months, but residual confounding cannot be excluded. In future prospective studies, investigators should reexamine this association in different age groups.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwr242</identifier><identifier>PMID: 22038100</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Asthma ; Asthma - epidemiology ; Asthma - etiology ; Biological and medical sciences ; Cesarean section ; Cesarean Section - adverse effects ; Cesarean Section - statistics & numerical data ; Child, Preschool ; Cohort Studies ; Delivery. Postpartum. Lactation ; Epidemiology ; Female ; General aspects ; Gynecology. Andrology. Obstetrics ; Health risk assessment ; Humans ; Infant ; Male ; Medical sciences ; Miscellaneous ; Newborn babies ; Norway - epidemiology ; Original Contributions ; Pneumonia - epidemiology ; Pregnancy ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Respiratory diseases ; Respiratory Sounds</subject><ispartof>American journal of epidemiology, 2011-12, Vol.174 (11), p.1275-1285</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Dec 1, 2011</rights><rights>American Journal of Epidemiology © The Author 2011. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-afd32f6e7f25200a4808e7ad463d0db70a5c5025faec81e354a8ac350cfea3963</citedby><cites>FETCH-LOGICAL-c500t-afd32f6e7f25200a4808e7ad463d0db70a5c5025faec81e354a8ac350cfea3963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25331885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22038100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAGNUS, Maria C</creatorcontrib><creatorcontrib>HABERG, Siri E</creatorcontrib><creatorcontrib>STIGUM, Hein</creatorcontrib><creatorcontrib>NAFSTAD, Per</creatorcontrib><creatorcontrib>LONDON, Stephanie J</creatorcontrib><creatorcontrib>VANGEN, Siri</creatorcontrib><creatorcontrib>NYSTAD, Wenche</creatorcontrib><title>Delivery by Cesarean Section and Early Childhood Respiratory Symptoms and Disorders: The Norwegian Mother and Child Cohort Study</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Studies have indicated that children delivered by cesarean section are at an increased risk of developing wheezing and asthma. This could be the result of an altered immune system development due to delayed gut colonization or of increased neonatal respiratory morbidity. The authors examined the associations between delivery by cesarean section and the development of wheezing, asthma, and recurrent lower respiratory tract infections in children up to 36 months of age among 37,171 children in the Norwegian Mother and Child Cohort Study. Generalized linear models were used in the multivariable analysis. Children delivered by cesarean section had an increased likelihood of current asthma at 36 months of age (relative risk = 1.17, 95% confidence interval: 1.03, 1.32), and the association was stronger among children of nonatopic mothers (relative risk = 1.33, 95% confidence interval: 1.12, 1.58). No increased risk of wheezing or recurrent lower respiratory tract infections was seen among children delivered by cesarean section. Findings were similar among children delivered by acute and elective cesarean section. In conclusion, children delivered by cesarean section may have an increased risk of current asthma at 36 months, but residual confounding cannot be excluded. In future prospective studies, investigators should reexamine this association in different age groups.</description><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>Biological and medical sciences</subject><subject>Cesarean section</subject><subject>Cesarean Section - adverse effects</subject><subject>Cesarean Section - statistics & numerical data</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Newborn babies</subject><subject>Norway - epidemiology</subject><subject>Original Contributions</subject><subject>Pneumonia - epidemiology</subject><subject>Pregnancy</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Respiratory diseases</subject><subject>Respiratory Sounds</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0U1v1DAQBmALgehSuPADkIWEkJBCx3acTXpAQtvyIRWQ2HK2ZuNJ4yUbL3bSKjd-Ou7uUj5OPswzr8Z6GXsq4LWASp3gmk6-3wSZy3tsJvJ5kRVSF_fZDABkVslCHrFHMa4BhKg0PGRHUoIqBcCM_Tyjzl1TmPhq4guKGAh7vqR6cL7n2Ft-jqFLo9Z1tvXe8q8Uty7g4NPOctpsB7-JO3jmog-WQjzlly3xzz7c0JVLaZ_80FLYmV0MX_jWh4Evh9FOj9mDBrtITw7vMfv27vxy8SG7-PL-4-LtRVZrgCHDxirZFDRvpJYAmJdQ0hxtXigLdjUH1AlK3SDVpSClcyyxVhrqhlBVhTpmb_a523G1IVtTPwTszDa4DYbJeHTm30nvWnPlr42SOhf6NuDlISD4HyPFwWxcrKnrsCc_RlNBoXVZ6jLJ5__JtR9Dn35nKiGrSmkBCb3aozr4GAM1d6cIMLe1mlSr2dea8LO_j7-jv3tM4MUBYKyxawL2tYt_nFZKpNvUL4VZrgQ</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>MAGNUS, Maria C</creator><creator>HABERG, Siri E</creator><creator>STIGUM, Hein</creator><creator>NAFSTAD, Per</creator><creator>LONDON, Stephanie J</creator><creator>VANGEN, Siri</creator><creator>NYSTAD, Wenche</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111201</creationdate><title>Delivery by Cesarean Section and Early Childhood Respiratory Symptoms and Disorders: The Norwegian Mother and Child Cohort Study</title><author>MAGNUS, Maria C ; HABERG, Siri E ; STIGUM, Hein ; NAFSTAD, Per ; LONDON, Stephanie J ; VANGEN, Siri ; NYSTAD, Wenche</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-afd32f6e7f25200a4808e7ad463d0db70a5c5025faec81e354a8ac350cfea3963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>Biological and medical sciences</topic><topic>Cesarean section</topic><topic>Cesarean Section - adverse effects</topic><topic>Cesarean Section - statistics & numerical data</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Newborn babies</topic><topic>Norway - epidemiology</topic><topic>Original Contributions</topic><topic>Pneumonia - epidemiology</topic><topic>Pregnancy</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Respiratory diseases</topic><topic>Respiratory Sounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAGNUS, Maria C</creatorcontrib><creatorcontrib>HABERG, Siri E</creatorcontrib><creatorcontrib>STIGUM, Hein</creatorcontrib><creatorcontrib>NAFSTAD, Per</creatorcontrib><creatorcontrib>LONDON, Stephanie J</creatorcontrib><creatorcontrib>VANGEN, Siri</creatorcontrib><creatorcontrib>NYSTAD, Wenche</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAGNUS, Maria C</au><au>HABERG, Siri E</au><au>STIGUM, Hein</au><au>NAFSTAD, Per</au><au>LONDON, Stephanie J</au><au>VANGEN, Siri</au><au>NYSTAD, Wenche</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delivery by Cesarean Section and Early Childhood Respiratory Symptoms and Disorders: The Norwegian Mother and Child Cohort Study</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>174</volume><issue>11</issue><spage>1275</spage><epage>1285</epage><pages>1275-1285</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Studies have indicated that children delivered by cesarean section are at an increased risk of developing wheezing and asthma. This could be the result of an altered immune system development due to delayed gut colonization or of increased neonatal respiratory morbidity. The authors examined the associations between delivery by cesarean section and the development of wheezing, asthma, and recurrent lower respiratory tract infections in children up to 36 months of age among 37,171 children in the Norwegian Mother and Child Cohort Study. Generalized linear models were used in the multivariable analysis. Children delivered by cesarean section had an increased likelihood of current asthma at 36 months of age (relative risk = 1.17, 95% confidence interval: 1.03, 1.32), and the association was stronger among children of nonatopic mothers (relative risk = 1.33, 95% confidence interval: 1.12, 1.58). No increased risk of wheezing or recurrent lower respiratory tract infections was seen among children delivered by cesarean section. Findings were similar among children delivered by acute and elective cesarean section. In conclusion, children delivered by cesarean section may have an increased risk of current asthma at 36 months, but residual confounding cannot be excluded. In future prospective studies, investigators should reexamine this association in different age groups.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>22038100</pmid><doi>10.1093/aje/kwr242</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Asthma Asthma - epidemiology Asthma - etiology Biological and medical sciences Cesarean section Cesarean Section - adverse effects Cesarean Section - statistics & numerical data Child, Preschool Cohort Studies Delivery. Postpartum. Lactation Epidemiology Female General aspects Gynecology. Andrology. Obstetrics Health risk assessment Humans Infant Male Medical sciences Miscellaneous Newborn babies Norway - epidemiology Original Contributions Pneumonia - epidemiology Pregnancy Public health. Hygiene Public health. Hygiene-occupational medicine Respiratory diseases Respiratory Sounds |
| title | Delivery by Cesarean Section and Early Childhood Respiratory Symptoms and Disorders: The Norwegian Mother and Child Cohort Study |
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