Time-resolved imaging refractometry of microbicidal films using quantitative phase microscopy
Quantitative phase microscopy is applied to image temporal changes in the refractive index (RI) distributions of solutions created by microbicidal films undergoing hydration. We present a novel method of using an engineered polydimethylsiloxane structure as a static phase reference to facilitate cal...
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| Veröffentlicht in: | Journal of Biomedical Optics 2011-12, Vol.16 (12), p.120510-120510 |
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| container_end_page | 120510 |
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| container_issue | 12 |
| container_start_page | 120510 |
| container_title | Journal of Biomedical Optics |
| container_volume | 16 |
| creator | Rinehart, Matthew T Drake, Tyler K Robles, Francisco E Wax, Adam P Rohan, Lisa C Katz, David F |
| description | Quantitative phase microscopy is applied to image temporal changes in the refractive index (RI) distributions of solutions created by microbicidal films undergoing hydration. We present a novel method of using an engineered polydimethylsiloxane structure as a static phase reference to facilitate calibration of the absolute RI across the entire field. We present a study of dynamic structural changes in microbicidal films during hydration and subsequent dissolution. With assumptions about the smoothness of the phase changes induced by these films, we calculate absolute changes in the percentage of film in regions across the field of view. |
| doi_str_mv | 10.1117/1.3665439 |
| format | Article |
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We present a novel method of using an engineered polydimethylsiloxane structure as a static phase reference to facilitate calibration of the absolute RI across the entire field. We present a study of dynamic structural changes in microbicidal films during hydration and subsequent dissolution. 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With assumptions about the smoothness of the phase changes induced by these films, we calculate absolute changes in the percentage of film in regions across the field of view.</description><subject>Anti-Infective Agents - chemistry</subject><subject>Dimethylpolysiloxanes - chemistry</subject><subject>JBO Letters</subject><subject>Microscopy - methods</subject><subject>Pharmaceutical Vehicles - chemistry</subject><subject>Refractometry - methods</subject><subject>Water - chemistry</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtr3DAUhUVpaF5d9A8U70oWTu6VbMneFJqhSRMCk8VkWYRGliYqtuVI9sD8-2oeHRoJJMH5OFf3XEK-IFwjorjBa8Z5WbD6AznDkkNOaYUf0xsqliepOiXnMf4BgIrX_BM5pRTrtOkZ-b1wncmDib5dmyZznVq5fpUFY4PSo-_MGDaZt1nndPBLp12j2sy6tovZFLfk26T60Y1qdGuTDa8qmj0btR82l-TEqjaaz4f7grzc_VzMfuVP8_uH2Y-nXBeVGHMBoraalRYaUdXCNoKpJQUURgNWTWkRAcqmpjW1QBkrGMISteaC64IXhl2Q73vfYVp2ptGmH4Nq5RBSP2EjvXLyvdK7V7nya8loyURJk8G3g0Hwb5OJo-xc1KZtVW_8FGXKiheU0SKRV3ty22NMOR2rIMjtNCTKwzQS-_X_bx3Jf_EngO6BODhzlB9v58938zQtQL47KVIoEXYL2V9MX5RH</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Rinehart, Matthew T</creator><creator>Drake, Tyler K</creator><creator>Robles, Francisco E</creator><creator>Wax, Adam P</creator><creator>Rohan, Lisa C</creator><creator>Katz, David F</creator><general>Society of Photo-Optical Instrumentation Engineers (SPIE)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111201</creationdate><title>Time-resolved imaging refractometry of microbicidal films using quantitative phase microscopy</title><author>Rinehart, Matthew T ; Drake, Tyler K ; Robles, Francisco E ; Wax, Adam P ; Rohan, Lisa C ; Katz, David F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-7079fc35f0d7897fd73ab2017ec018d5f11005d9292f02334310b1cc676c464e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anti-Infective Agents - chemistry</topic><topic>Dimethylpolysiloxanes - chemistry</topic><topic>JBO Letters</topic><topic>Microscopy - methods</topic><topic>Pharmaceutical Vehicles - chemistry</topic><topic>Refractometry - methods</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rinehart, Matthew T</creatorcontrib><creatorcontrib>Drake, Tyler K</creatorcontrib><creatorcontrib>Robles, Francisco E</creatorcontrib><creatorcontrib>Wax, Adam P</creatorcontrib><creatorcontrib>Rohan, Lisa C</creatorcontrib><creatorcontrib>Katz, David F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Biomedical Optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rinehart, Matthew T</au><au>Drake, Tyler K</au><au>Robles, Francisco E</au><au>Wax, Adam P</au><au>Rohan, Lisa C</au><au>Katz, David F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time-resolved imaging refractometry of microbicidal films using quantitative phase microscopy</atitle><jtitle>Journal of Biomedical Optics</jtitle><addtitle>J Biomed Opt</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>16</volume><issue>12</issue><spage>120510</spage><epage>120510</epage><pages>120510-120510</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><coden>JBOPFO</coden><abstract>Quantitative phase microscopy is applied to image temporal changes in the refractive index (RI) distributions of solutions created by microbicidal films undergoing hydration. 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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anti-Infective Agents - chemistry Dimethylpolysiloxanes - chemistry JBO Letters Microscopy - methods Pharmaceutical Vehicles - chemistry Refractometry - methods Water - chemistry |
| title | Time-resolved imaging refractometry of microbicidal films using quantitative phase microscopy |
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