B-Cell Aortic Homing and Atheroprotection Depend on Id3

RATIONALE:B cells are abundant in the adventitia of normal and diseased vessels. Yet, the molecular and cellular mechanisms mediating homing of B cells to the vessel wall and B-cell effects on atherosclerosis are poorly understood. Inhibitor of differentiation-3 (Id3) is important for atheroprotecti...

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Veröffentlicht in:	Circulation research 2012-01, Vol.110 (1), p.e1-e12
Hauptverfasser:	Doran, Amanda C, Lipinski, Michael J, Oldham, Stephanie N, Garmey, James C, Campbell, Kirsti A, Skaflen, Marcus D, Cutchins, Alexis, Lee, Daniel J, Glover, David K, Kelly, Kimberly A, Galkina, Elena V, Ley, Klaus, Witztum, Joseph L, Tsimikas, Sotirios, Bender, Timothy P, McNamara, Coleen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - pathology Aorta - physiopathology Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis - etiology Atherosclerosis - physiopathology Atherosclerosis - prevention & control B-Lymphocytes - pathology B-Lymphocytes - physiology Cell Movement - physiology Diet - adverse effects Disease Models, Animal Disease Progression Incidence Inhibitor of Differentiation Proteins - deficiency Inhibitor of Differentiation Proteins - genetics Inhibitor of Differentiation Proteins - physiology Mice Mice, Knockout Plaque, Atherosclerotic - pathology Plaque, Atherosclerotic - physiopathology Receptors, CCR6 - physiology Signal Transduction - physiology
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