Optical imaging of plastic changes induced by fear conditioning in the auditory cortex
The plastic changes in the auditory cortex induced by a fear conditioning, through pairing a sound (CS) with an electric foot-shock (US), were investigated using an optical recording method with voltage sensitive dye, RH795. In order to investigate the effects of association learning, optical signal...
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| Veröffentlicht in: | Cognitive neurodynamics 2012-02, Vol.6 (1), p.1-10 |
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| creator | Ide, Yoshinori Miyazaki, Takashi Lauwereyns, Johan Sandner, Guy Tsukada, Minoru Aihara, Takeshi |
| description | The plastic changes in the auditory cortex induced by a fear conditioning, through pairing a sound (CS) with an electric foot-shock (US), were investigated using an optical recording method with voltage sensitive dye, RH795. In order to investigate the effects of association learning, optical signals in the auditory cortex in response to CS (12 kHz pure tone) and non-CS (4, 8, 16 kHz pure tone) were recorded before and after normal and sham conditioning. As a result, the response area to CS enlarged only in the conditioning group after the conditioning. Additionally, the rise time constant of the auditory response to CS significantly decreased and the relative peak value and the decay time constant of the auditory response to CS significantly increased after the conditioning. This study introduces an optical approach to the investigation of fear conditioning, representational plasticity, and the cholinergic system. The findings are synthesized in a model of the synaptic mechanisms that underlie cortical plasticity. |
| doi_str_mv | 10.1007/s11571-011-9173-x |
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In order to investigate the effects of association learning, optical signals in the auditory cortex in response to CS (12 kHz pure tone) and non-CS (4, 8, 16 kHz pure tone) were recorded before and after normal and sham conditioning. As a result, the response area to CS enlarged only in the conditioning group after the conditioning. Additionally, the rise time constant of the auditory response to CS significantly decreased and the relative peak value and the decay time constant of the auditory response to CS significantly increased after the conditioning. This study introduces an optical approach to the investigation of fear conditioning, representational plasticity, and the cholinergic system. The findings are synthesized in a model of the synaptic mechanisms that underlie cortical plasticity.</description><identifier>ISSN: 1871-4080</identifier><identifier>EISSN: 1871-4099</identifier><identifier>DOI: 10.1007/s11571-011-9173-x</identifier><identifier>PMID: 23372615</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Artificial Intelligence ; Associative learning ; Bats ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cholinergic transmission ; Cholinergics ; Cognitive Psychology ; Computer Science ; Conditioned stimulus ; Cortex (auditory) ; Experiments ; Fear conditioning ; Footshock ; Hearing ; Hypotheses ; Ketamine ; Neuroimaging ; Neuroplasticity ; Neurosciences ; Optical communication ; Research Article ; Sound ; Synaptic plasticity ; Time constant</subject><ispartof>Cognitive neurodynamics, 2012-02, Vol.6 (1), p.1-10</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2011.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-bf52b5222dae3f4fadc06ab5efeea372a41a62f2446b8cd85ef5e3b87104fa403</citedby><cites>FETCH-LOGICAL-c536t-bf52b5222dae3f4fadc06ab5efeea372a41a62f2446b8cd85ef5e3b87104fa403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253167/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918678827?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,21388,21389,27924,27925,33530,33531,33744,33745,41488,42557,43659,43805,51319,53791,53793,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23372615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ide, Yoshinori</creatorcontrib><creatorcontrib>Miyazaki, Takashi</creatorcontrib><creatorcontrib>Lauwereyns, Johan</creatorcontrib><creatorcontrib>Sandner, Guy</creatorcontrib><creatorcontrib>Tsukada, Minoru</creatorcontrib><creatorcontrib>Aihara, Takeshi</creatorcontrib><title>Optical imaging of plastic changes induced by fear conditioning in the auditory cortex</title><title>Cognitive neurodynamics</title><addtitle>Cogn Neurodyn</addtitle><addtitle>Cogn Neurodyn</addtitle><description>The plastic changes in the auditory cortex induced by a fear conditioning, through pairing a sound (CS) with an electric foot-shock (US), were investigated using an optical recording method with voltage sensitive dye, RH795. 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The findings are synthesized in a model of the synaptic mechanisms that underlie cortical plasticity.</description><subject>Artificial Intelligence</subject><subject>Associative learning</subject><subject>Bats</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cholinergic transmission</subject><subject>Cholinergics</subject><subject>Cognitive Psychology</subject><subject>Computer Science</subject><subject>Conditioned stimulus</subject><subject>Cortex (auditory)</subject><subject>Experiments</subject><subject>Fear conditioning</subject><subject>Footshock</subject><subject>Hearing</subject><subject>Hypotheses</subject><subject>Ketamine</subject><subject>Neuroimaging</subject><subject>Neuroplasticity</subject><subject>Neurosciences</subject><subject>Optical communication</subject><subject>Research Article</subject><subject>Sound</subject><subject>Synaptic plasticity</subject><subject>Time constant</subject><issn>1871-4080</issn><issn>1871-4099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUuLFDEUhYMozjj6A9xIwI2b0tykUpXeCDL4goHZqNuQSt10Z6hO2qRKuv-9t-mxfYCrhHu-nNzDYew5iNcgRP-mAugeGgHQrKBXzf4BuwRDk1asVg_PdyMu2JNa74TQnYH2MbuQSvWyA33Jvt3u5ujdxOPWrWNa8xz4bnKVhtxvXFpj5TGNi8eRDwce0BXucxrjHHM68jHxeYPcLTTK5UBimXH_lD0Kbqr47P68Yl8_vP9y_am5uf34-frdTeO16uZmCFoOWko5OlShDW70onODxoDoaEXXgutkkG3bDcaPhgSNaqBYguBWqCv29uS7W4Ytjh7TXNxkd4XilIPNLtq_lRQ3dp1_WCW1gq4ng1f3BiV_X7DOdhurx2lyCfNSLUijeiVaAYS-_Ae9y0tJFM_KFZiuN0YeDeFE-ZJrLRjOy4Cwx9bsqTVLrdlja3ZPb178meL84ldNBMgTUEmiTsrvr__v-hMgdKT5</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Ide, Yoshinori</creator><creator>Miyazaki, Takashi</creator><creator>Lauwereyns, Johan</creator><creator>Sandner, Guy</creator><creator>Tsukada, Minoru</creator><creator>Aihara, Takeshi</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120201</creationdate><title>Optical imaging of plastic changes induced by fear conditioning in the auditory cortex</title><author>Ide, Yoshinori ; Miyazaki, Takashi ; Lauwereyns, Johan ; Sandner, Guy ; Tsukada, Minoru ; Aihara, Takeshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-bf52b5222dae3f4fadc06ab5efeea372a41a62f2446b8cd85ef5e3b87104fa403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Artificial Intelligence</topic><topic>Associative learning</topic><topic>Bats</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cholinergic transmission</topic><topic>Cholinergics</topic><topic>Cognitive Psychology</topic><topic>Computer Science</topic><topic>Conditioned stimulus</topic><topic>Cortex (auditory)</topic><topic>Experiments</topic><topic>Fear conditioning</topic><topic>Footshock</topic><topic>Hearing</topic><topic>Hypotheses</topic><topic>Ketamine</topic><topic>Neuroimaging</topic><topic>Neuroplasticity</topic><topic>Neurosciences</topic><topic>Optical communication</topic><topic>Research Article</topic><topic>Sound</topic><topic>Synaptic plasticity</topic><topic>Time constant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ide, Yoshinori</creatorcontrib><creatorcontrib>Miyazaki, Takashi</creatorcontrib><creatorcontrib>Lauwereyns, Johan</creatorcontrib><creatorcontrib>Sandner, Guy</creatorcontrib><creatorcontrib>Tsukada, Minoru</creatorcontrib><creatorcontrib>Aihara, Takeshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cognitive neurodynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ide, Yoshinori</au><au>Miyazaki, Takashi</au><au>Lauwereyns, Johan</au><au>Sandner, Guy</au><au>Tsukada, Minoru</au><au>Aihara, Takeshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optical imaging of plastic changes induced by fear conditioning in the auditory cortex</atitle><jtitle>Cognitive neurodynamics</jtitle><stitle>Cogn Neurodyn</stitle><addtitle>Cogn Neurodyn</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>6</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1871-4080</issn><eissn>1871-4099</eissn><abstract>The plastic changes in the auditory cortex induced by a fear conditioning, through pairing a sound (CS) with an electric foot-shock (US), were investigated using an optical recording method with voltage sensitive dye, RH795. 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| subjects | Artificial Intelligence Associative learning Bats Biochemistry Biomedical and Life Sciences Biomedicine Cholinergic transmission Cholinergics Cognitive Psychology Computer Science Conditioned stimulus Cortex (auditory) Experiments Fear conditioning Footshock Hearing Hypotheses Ketamine Neuroimaging Neuroplasticity Neurosciences Optical communication Research Article Sound Synaptic plasticity Time constant |
| title | Optical imaging of plastic changes induced by fear conditioning in the auditory cortex |
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