Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature
Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory pathways, and long-term use of anti-inflammatory drugs is linked with reduced risk to develop the disease. As cause and effect relationships betwe...
Gespeichert in:
| Veröffentlicht in: | Cold Spring Harbor perspectives in medicine 2012-01, Vol.2 (1), p.a006346-a006346 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | a006346 |
|---|---|
| container_issue | 1 |
| container_start_page | a006346 |
| container_title | Cold Spring Harbor perspectives in medicine |
| container_volume | 2 |
| creator | Wyss-Coray, Tony Rogers, Joseph |
| description | Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory pathways, and long-term use of anti-inflammatory drugs is linked with reduced risk to develop the disease. As cause and effect relationships between inflammation and AD are being worked out, there is a realization that some components of this complex molecular and cellular machinery are most likely promoting pathological processes leading to AD, whereas other components serve to do the opposite. The challenge will be to find ways of fine tuning inflammation to delay, prevent, or treat AD. |
| doi_str_mv | 10.1101/cshperspect.a006346 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3253025</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>920787667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-e9c97bd792dfa5bcc139858a705f1188580b97e08fb22763f0bfb3dd6e593a563</originalsourceid><addsrcrecordid>eNpVUV1LHTEQDaWil6u_QCh569NqPjbJ7ktBpFVB6Ev7KGGSnfSmZLO3yd5b7K_vilfRgWEOnDNnBg4h55xdcM74pa-bLZa6RT9fAGNatvoDWYnWiEa1XHxcMFem4a0QJ-Ss1t9sKaV1Z9gxORFCLixvV-ThLocE4whznDKNmV6lfxuMIxY6xIpQsQHqSsRAC-4j_qVToPMGqYMaPa0-YvZIIQ_Up5ijh0RTnLHAvCt4So4CpIpnh7kmP799_XF929x_v7m7vrpvfGvY3GDve-MG04shgHLec9l3qgPDVOC8WyBzvUHWBSeE0TIwF5wcBo2ql6C0XJMvz77bnRtx8JjnAsluSxyhPNoJon3P5Lixv6a9lUJJtvSafD4YlOnPDutsx1g9pgQZp121vWCmM1qbRSmflb5MtRYMr1c4s0_R2DfR2EM0y9antw--7rwEIf8DpjCPuQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>920787667</pqid></control><display><type>article</type><title>Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wyss-Coray, Tony ; Rogers, Joseph</creator><creatorcontrib>Wyss-Coray, Tony ; Rogers, Joseph</creatorcontrib><description>Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory pathways, and long-term use of anti-inflammatory drugs is linked with reduced risk to develop the disease. As cause and effect relationships between inflammation and AD are being worked out, there is a realization that some components of this complex molecular and cellular machinery are most likely promoting pathological processes leading to AD, whereas other components serve to do the opposite. The challenge will be to find ways of fine tuning inflammation to delay, prevent, or treat AD.</description><identifier>ISSN: 2157-1422</identifier><identifier>EISSN: 2472-5412</identifier><identifier>DOI: 10.1101/cshperspect.a006346</identifier><identifier>PMID: 22315714</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Alzheimer Disease - genetics ; Alzheimer Disease - pathology ; Alzheimer Disease - prevention & control ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Arachidonic Acid - metabolism ; Astrocytes - pathology ; Clinical Trials as Topic ; Complement Activation - physiology ; Complement System Proteins - physiology ; Cytokines - physiology ; Encephalitis - pathology ; Humans ; Mice ; Microglia - pathology ; Neurons - pathology ; Oligodendroglia - pathology ; Polymorphism, Genetic - genetics ; Prostaglandin-Endoperoxide Synthases - physiology ; Toll-Like Receptors - physiology</subject><ispartof>Cold Spring Harbor perspectives in medicine, 2012-01, Vol.2 (1), p.a006346-a006346</ispartof><rights>Copyright © 2012 Cold Spring Harbor Laboratory Press; all rights reserved 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-e9c97bd792dfa5bcc139858a705f1188580b97e08fb22763f0bfb3dd6e593a563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253025/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253025/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22315714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wyss-Coray, Tony</creatorcontrib><creatorcontrib>Rogers, Joseph</creatorcontrib><title>Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature</title><title>Cold Spring Harbor perspectives in medicine</title><addtitle>Cold Spring Harb Perspect Med</addtitle><description>Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory pathways, and long-term use of anti-inflammatory drugs is linked with reduced risk to develop the disease. As cause and effect relationships between inflammation and AD are being worked out, there is a realization that some components of this complex molecular and cellular machinery are most likely promoting pathological processes leading to AD, whereas other components serve to do the opposite. The challenge will be to find ways of fine tuning inflammation to delay, prevent, or treat AD.</description><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - prevention & control</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Arachidonic Acid - metabolism</subject><subject>Astrocytes - pathology</subject><subject>Clinical Trials as Topic</subject><subject>Complement Activation - physiology</subject><subject>Complement System Proteins - physiology</subject><subject>Cytokines - physiology</subject><subject>Encephalitis - pathology</subject><subject>Humans</subject><subject>Mice</subject><subject>Microglia - pathology</subject><subject>Neurons - pathology</subject><subject>Oligodendroglia - pathology</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Prostaglandin-Endoperoxide Synthases - physiology</subject><subject>Toll-Like Receptors - physiology</subject><issn>2157-1422</issn><issn>2472-5412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUV1LHTEQDaWil6u_QCh569NqPjbJ7ktBpFVB6Ev7KGGSnfSmZLO3yd5b7K_vilfRgWEOnDNnBg4h55xdcM74pa-bLZa6RT9fAGNatvoDWYnWiEa1XHxcMFem4a0QJ-Ss1t9sKaV1Z9gxORFCLixvV-ThLocE4whznDKNmV6lfxuMIxY6xIpQsQHqSsRAC-4j_qVToPMGqYMaPa0-YvZIIQ_Up5ijh0RTnLHAvCt4So4CpIpnh7kmP799_XF929x_v7m7vrpvfGvY3GDve-MG04shgHLec9l3qgPDVOC8WyBzvUHWBSeE0TIwF5wcBo2ql6C0XJMvz77bnRtx8JjnAsluSxyhPNoJon3P5Lixv6a9lUJJtvSafD4YlOnPDutsx1g9pgQZp121vWCmM1qbRSmflb5MtRYMr1c4s0_R2DfR2EM0y9antw--7rwEIf8DpjCPuQ</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Wyss-Coray, Tony</creator><creator>Rogers, Joseph</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature</title><author>Wyss-Coray, Tony ; Rogers, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-e9c97bd792dfa5bcc139858a705f1188580b97e08fb22763f0bfb3dd6e593a563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - prevention & control</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Arachidonic Acid - metabolism</topic><topic>Astrocytes - pathology</topic><topic>Clinical Trials as Topic</topic><topic>Complement Activation - physiology</topic><topic>Complement System Proteins - physiology</topic><topic>Cytokines - physiology</topic><topic>Encephalitis - pathology</topic><topic>Humans</topic><topic>Mice</topic><topic>Microglia - pathology</topic><topic>Neurons - pathology</topic><topic>Oligodendroglia - pathology</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Prostaglandin-Endoperoxide Synthases - physiology</topic><topic>Toll-Like Receptors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wyss-Coray, Tony</creatorcontrib><creatorcontrib>Rogers, Joseph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cold Spring Harbor perspectives in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wyss-Coray, Tony</au><au>Rogers, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature</atitle><jtitle>Cold Spring Harbor perspectives in medicine</jtitle><addtitle>Cold Spring Harb Perspect Med</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2</volume><issue>1</issue><spage>a006346</spage><epage>a006346</epage><pages>a006346-a006346</pages><issn>2157-1422</issn><eissn>2472-5412</eissn><abstract>Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory pathways, and long-term use of anti-inflammatory drugs is linked with reduced risk to develop the disease. As cause and effect relationships between inflammation and AD are being worked out, there is a realization that some components of this complex molecular and cellular machinery are most likely promoting pathological processes leading to AD, whereas other components serve to do the opposite. The challenge will be to find ways of fine tuning inflammation to delay, prevent, or treat AD.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>22315714</pmid><doi>10.1101/cshperspect.a006346</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2157-1422 |
| ispartof | Cold Spring Harbor perspectives in medicine, 2012-01, Vol.2 (1), p.a006346-a006346 |
| issn | 2157-1422 2472-5412 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3253025 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - prevention & control Animals Anti-Inflammatory Agents - therapeutic use Arachidonic Acid - metabolism Astrocytes - pathology Clinical Trials as Topic Complement Activation - physiology Complement System Proteins - physiology Cytokines - physiology Encephalitis - pathology Humans Mice Microglia - pathology Neurons - pathology Oligodendroglia - pathology Polymorphism, Genetic - genetics Prostaglandin-Endoperoxide Synthases - physiology Toll-Like Receptors - physiology |
| title | Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T11%3A49%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inflammation%20in%20Alzheimer%20disease-a%20brief%20review%20of%20the%20basic%20science%20and%20clinical%20literature&rft.jtitle=Cold%20Spring%20Harbor%20perspectives%20in%20medicine&rft.au=Wyss-Coray,%20Tony&rft.date=2012-01-01&rft.volume=2&rft.issue=1&rft.spage=a006346&rft.epage=a006346&rft.pages=a006346-a006346&rft.issn=2157-1422&rft.eissn=2472-5412&rft_id=info:doi/10.1101/cshperspect.a006346&rft_dat=%3Cproquest_pubme%3E920787667%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=920787667&rft_id=info:pmid/22315714&rfr_iscdi=true |