Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti‐tumour efficacy

BACKGROUND AND PURPOSE Our previous studies demonstrated that a thiosemicarbazone iron chelator (di‐2‐pyridylketone‐4,4‐dimethyl‐3‐thiosemicarbazone; Dp44mT) possesses potent and selective anti‐cancer activity but led to cardiotoxicity at non‐optimal doses. In this study, we examined the in vivo ant...

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Veröffentlicht in:	British journal of pharmacology 2012-01, Vol.165 (1), p.148-166
Hauptverfasser:	Yu, Y, Rahmanto, Y Suryo, Richardson, DR
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents - pharmacology anti‐tumour chemotherapeutic Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Resistance, Neoplasm Humans Injections, Intravenous Iron Chelating Agents - pharmacology iron chelator Lung Neoplasms - drug therapy Medical sciences Mice Molecular Structure Neoplasms, Experimental - drug therapy oral activity Pharmacology. Drug treatments Pyridines - classification Pyridines - pharmacology Research Papers Thiosemicarbazones - classification Thiosemicarbazones - pharmacology
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