Reduction of Theta Rhythm Dissociates Grid Cell Spatial Periodicity from Directional Tuning
Grid cells recorded in the medial entorhinal cortex of freely moving rats exhibit firing at regular spatial locations and temporal modulation with theta rhythm oscillations (4 to 11 hertz). We analyzed grid cell spatial coding during reduction of network theta rhythm oscillations caused by medial se...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2011-04, Vol.332 (6029), p.595-599 |
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| creator | Brandon, Mark P. Bogaard, Andrew R. Libby, Christopher P. Connerney, Michael A. Gupta, Kishan Hasselmo, Michael E. |
| description | Grid cells recorded in the medial entorhinal cortex of freely moving rats exhibit firing at regular spatial locations and temporal modulation with theta rhythm oscillations (4 to 11 hertz). We analyzed grid cell spatial coding during reduction of network theta rhythm oscillations caused by medial septum (MS) inactivation with muscimol. During MS inactivation, grid cells lost their spatial periodicity, whereas head-direction cells maintained their selectivity. Conjunctive grid—by—head-direction cells lost grid cell spatial periodicity but retained head-direction specificity. All cells showed reduced rhythmicity in autocorrelations and cross-correlations. This supports the hypothesis that spatial coding by grid cells requires theta oscillations, and dissociates the mechanisms underlying the generation of entorhinal grid cell periodicity and head-direction selectivity. |
| doi_str_mv | 10.1126/science.1201652 |
| format | Article |
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We analyzed grid cell spatial coding during reduction of network theta rhythm oscillations caused by medial septum (MS) inactivation with muscimol. During MS inactivation, grid cells lost their spatial periodicity, whereas head-direction cells maintained their selectivity. Conjunctive grid—by—head-direction cells lost grid cell spatial periodicity but retained head-direction specificity. All cells showed reduced rhythmicity in autocorrelations and cross-correlations. This supports the hypothesis that spatial coding by grid cells requires theta oscillations, and dissociates the mechanisms underlying the generation of entorhinal grid cell periodicity and head-direction selectivity.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1201652</identifier><identifier>PMID: 21527714</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Autocorrelation ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Cellular biology ; Coding ; Electrophysiology ; Entorhinal cortex ; Entorhinal Cortex - cytology ; Entorhinal Cortex - physiology ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Inactivation ; Male ; Membrane Potentials ; Memory ; Modulation ; Motor Activity ; Muscimol - pharmacology ; Nerve Net - physiology ; Neural Pathways ; Neurons ; Neurons - physiology ; Oscillations ; Periodicity ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Long-Evans ; Reduction ; Rhythm ; Rodents ; Selectivity ; Septum ; Septum Pellucidum - drug effects ; Septum Pellucidum - physiology ; Space Perception ; Spatial data ; Theta rhythm ; Theta Rhythm - drug effects ; Tuning</subject><ispartof>Science (American Association for the Advancement of Science), 2011-04, Vol.332 (6029), p.595-599</ispartof><rights>Copyright © 2011 The American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c615t-53874482fb22609ae7eda1b1d006475681e548a0beb1c6bad36fc4e6e3d35ca23</citedby><cites>FETCH-LOGICAL-c615t-53874482fb22609ae7eda1b1d006475681e548a0beb1c6bad36fc4e6e3d35ca23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29784180$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29784180$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24153872$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21527714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brandon, Mark P.</creatorcontrib><creatorcontrib>Bogaard, Andrew R.</creatorcontrib><creatorcontrib>Libby, Christopher P.</creatorcontrib><creatorcontrib>Connerney, Michael A.</creatorcontrib><creatorcontrib>Gupta, Kishan</creatorcontrib><creatorcontrib>Hasselmo, Michael E.</creatorcontrib><title>Reduction of Theta Rhythm Dissociates Grid Cell Spatial Periodicity from Directional Tuning</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Grid cells recorded in the medial entorhinal cortex of freely moving rats exhibit firing at regular spatial locations and temporal modulation with theta rhythm oscillations (4 to 11 hertz). We analyzed grid cell spatial coding during reduction of network theta rhythm oscillations caused by medial septum (MS) inactivation with muscimol. During MS inactivation, grid cells lost their spatial periodicity, whereas head-direction cells maintained their selectivity. Conjunctive grid—by—head-direction cells lost grid cell spatial periodicity but retained head-direction specificity. All cells showed reduced rhythmicity in autocorrelations and cross-correlations. This supports the hypothesis that spatial coding by grid cells requires theta oscillations, and dissociates the mechanisms underlying the generation of entorhinal grid cell periodicity and head-direction selectivity.</description><subject>Animals</subject><subject>Autocorrelation</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cellular biology</subject><subject>Coding</subject><subject>Electrophysiology</subject><subject>Entorhinal cortex</subject><subject>Entorhinal Cortex - cytology</subject><subject>Entorhinal Cortex - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Inactivation</subject><subject>Male</subject><subject>Membrane Potentials</subject><subject>Memory</subject><subject>Modulation</subject><subject>Motor Activity</subject><subject>Muscimol - pharmacology</subject><subject>Nerve Net - physiology</subject><subject>Neural Pathways</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Oscillations</subject><subject>Periodicity</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Reduction</subject><subject>Rhythm</subject><subject>Rodents</subject><subject>Selectivity</subject><subject>Septum</subject><subject>Septum Pellucidum - drug effects</subject><subject>Septum Pellucidum - physiology</subject><subject>Space Perception</subject><subject>Spatial data</subject><subject>Theta rhythm</subject><subject>Theta Rhythm - drug effects</subject><subject>Tuning</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EotvCmRPIQqp6SuvvJBcktECpVAlUlhMHy3EmXa-y8WI7SPvf47BpS7lwGPnwfn6aeQ-hV5ScU8rURbQOBgvnlBGqJHuCFpTUsqgZ4U_RghCuioqU8ggdx7ghJGs1f46OGJWsLKlYoB830I42OT9g3-HVGpLBN-t9Wm_xBxejt84kiPgyuBYvoe_xt51JzvT4KwTnW2dd2uMu-AkP8Mcoi6txcMPtC_SsM32El_N7gr5_-rhafi6uv1xeLd9fF1ZRmQrJq1KIinUNY4rUBkpoDW1oS4gSpVQVBSkqQxpoqFWNabnqrAAFvOXSGsZP0LuD725sttBaGFIwvd4FtzVhr71x-rEyuLW-9b80ZzkGpbLB2WwQ_M8RYtJbF22-1gzgx6hrUtaCUVb-l6yUoLXMk8m3_5AbP4YczgTxmnNBeIYuDpANPsYA3f3SlOipYD0XrOeC8483f996z981moHTGTDRmr4LZrAuPnCCTnlPRq8P3CYmHx70uqwErQj_DXMTucg</recordid><startdate>20110429</startdate><enddate>20110429</enddate><creator>Brandon, Mark P.</creator><creator>Bogaard, Andrew R.</creator><creator>Libby, Christopher P.</creator><creator>Connerney, Michael A.</creator><creator>Gupta, Kishan</creator><creator>Hasselmo, Michael E.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110429</creationdate><title>Reduction of Theta Rhythm Dissociates Grid Cell Spatial Periodicity from Directional Tuning</title><author>Brandon, Mark P. ; Bogaard, Andrew R. ; Libby, Christopher P. ; Connerney, Michael A. ; Gupta, Kishan ; Hasselmo, Michael E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c615t-53874482fb22609ae7eda1b1d006475681e548a0beb1c6bad36fc4e6e3d35ca23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Autocorrelation</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cellular biology</topic><topic>Coding</topic><topic>Electrophysiology</topic><topic>Entorhinal cortex</topic><topic>Entorhinal Cortex - cytology</topic><topic>Entorhinal Cortex - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Inactivation</topic><topic>Male</topic><topic>Membrane Potentials</topic><topic>Memory</topic><topic>Modulation</topic><topic>Motor Activity</topic><topic>Muscimol - pharmacology</topic><topic>Nerve Net - physiology</topic><topic>Neural Pathways</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Oscillations</topic><topic>Periodicity</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Reduction</topic><topic>Rhythm</topic><topic>Rodents</topic><topic>Selectivity</topic><topic>Septum</topic><topic>Septum Pellucidum - drug effects</topic><topic>Septum Pellucidum - physiology</topic><topic>Space Perception</topic><topic>Spatial data</topic><topic>Theta rhythm</topic><topic>Theta Rhythm - drug effects</topic><topic>Tuning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brandon, Mark P.</creatorcontrib><creatorcontrib>Bogaard, Andrew R.</creatorcontrib><creatorcontrib>Libby, Christopher P.</creatorcontrib><creatorcontrib>Connerney, Michael A.</creatorcontrib><creatorcontrib>Gupta, Kishan</creatorcontrib><creatorcontrib>Hasselmo, Michael E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brandon, Mark P.</au><au>Bogaard, Andrew R.</au><au>Libby, Christopher P.</au><au>Connerney, Michael A.</au><au>Gupta, Kishan</au><au>Hasselmo, Michael E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of Theta Rhythm Dissociates Grid Cell Spatial Periodicity from Directional Tuning</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2011-04-29</date><risdate>2011</risdate><volume>332</volume><issue>6029</issue><spage>595</spage><epage>599</epage><pages>595-599</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Grid cells recorded in the medial entorhinal cortex of freely moving rats exhibit firing at regular spatial locations and temporal modulation with theta rhythm oscillations (4 to 11 hertz). We analyzed grid cell spatial coding during reduction of network theta rhythm oscillations caused by medial septum (MS) inactivation with muscimol. During MS inactivation, grid cells lost their spatial periodicity, whereas head-direction cells maintained their selectivity. Conjunctive grid—by—head-direction cells lost grid cell spatial periodicity but retained head-direction specificity. All cells showed reduced rhythmicity in autocorrelations and cross-correlations. This supports the hypothesis that spatial coding by grid cells requires theta oscillations, and dissociates the mechanisms underlying the generation of entorhinal grid cell periodicity and head-direction selectivity.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>21527714</pmid><doi>10.1126/science.1201652</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Autocorrelation Behavioral psychophysiology Biological and medical sciences Brain Cellular biology Coding Electrophysiology Entorhinal cortex Entorhinal Cortex - cytology Entorhinal Cortex - physiology Fundamental and applied biological sciences. Psychology Hippocampus Inactivation Male Membrane Potentials Memory Modulation Motor Activity Muscimol - pharmacology Nerve Net - physiology Neural Pathways Neurons Neurons - physiology Oscillations Periodicity Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Long-Evans Reduction Rhythm Rodents Selectivity Septum Septum Pellucidum - drug effects Septum Pellucidum - physiology Space Perception Spatial data Theta rhythm Theta Rhythm - drug effects Tuning |
| title | Reduction of Theta Rhythm Dissociates Grid Cell Spatial Periodicity from Directional Tuning |
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