Value of sperm chromatin dispersion test in couples with unexplained recurrent abortion
Objective To evaluate and compare standard sperm parameters and sperm chromatin integrity by sperm chromatin dispersion test (SCD) in ejaculates from men whose partners have a history of recurrent pregnancy loss and from control group of fertile men. Methods Thirty couples with unexplained recurrent...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2012-01, Vol.29 (1), p.11-14 |
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| creator | Absalan, Forouzan Ghannadi, Alireza Kazerooni, Marjaneh Parifar, Rostami Jamalzadeh, Fatemeh Amiri, Sahar |
| description | Objective
To evaluate and compare standard sperm parameters and sperm chromatin integrity by sperm chromatin dispersion test (SCD) in ejaculates from men whose partners have a history of recurrent pregnancy loss and from control group of fertile men.
Methods
Thirty couples with unexplained recurrent abortion (case group) and 30 fertile couples (control group) referring to Shiraz infertility center were included. Sperm parameters were assessed in semen samples from two groups and then staining with SCD procedure. The results were analyzed by performing ANOVA and Tukey
,
s tests.
Results
In control group, nucleoids with big (65.93 ± 2.35), small (12.4 ± 0.60) and without halo (11.6 ± 0.50) showed significant difference with case group (41.40 ± 1.43), (21.16 ± 1.11) and (23.26 ± 1.10) respectively. In the RPL group spermatozoa with high percentage of abnormal parameters (morphology and motility) was observed (
p
≤ 0.05).
Conclusion
This study strengthens the current literature associating sperm quality with recurrent pregnancy loss, and emphasizes the important of evaluating male factor by tests such as SCD in addition to conventional sperm parameters. |
| doi_str_mv | 10.1007/s10815-011-9647-0 |
| format | Article |
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To evaluate and compare standard sperm parameters and sperm chromatin integrity by sperm chromatin dispersion test (SCD) in ejaculates from men whose partners have a history of recurrent pregnancy loss and from control group of fertile men.
Methods
Thirty couples with unexplained recurrent abortion (case group) and 30 fertile couples (control group) referring to Shiraz infertility center were included. Sperm parameters were assessed in semen samples from two groups and then staining with SCD procedure. The results were analyzed by performing ANOVA and Tukey
,
s tests.
Results
In control group, nucleoids with big (65.93 ± 2.35), small (12.4 ± 0.60) and without halo (11.6 ± 0.50) showed significant difference with case group (41.40 ± 1.43), (21.16 ± 1.11) and (23.26 ± 1.10) respectively. In the RPL group spermatozoa with high percentage of abnormal parameters (morphology and motility) was observed (
p
≤ 0.05).
Conclusion
This study strengthens the current literature associating sperm quality with recurrent pregnancy loss, and emphasizes the important of evaluating male factor by tests such as SCD in addition to conventional sperm parameters.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-011-9647-0</identifier><identifier>PMID: 22009642</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Abortion ; Abortion, Habitual - genetics ; Abortion, Habitual - metabolism ; Chromatin ; Chromatin - chemistry ; Chromatin - metabolism ; DNA damage ; DNA Fragmentation ; Female ; Gamete Biology ; Gynecology ; Human Genetics ; Humans ; In vitro fertilization ; Infertility ; Male ; Medicine ; Medicine & Public Health ; Miscarriage ; Morphology ; Motility ; Nucleoids ; Pregnancy ; Proteins ; Reproductive Medicine ; Semen ; Sperm ; Sperm Count ; Sperm Motility - genetics ; Spermatozoa - cytology ; Spermatozoa - metabolism</subject><ispartof>Journal of assisted reproduction and genetics, 2012-01, Vol.29 (1), p.11-14</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-a0fdd79bb48554c74c900f3755d3599f2f765e2904e424dda80c7f0641abf8dc3</citedby><cites>FETCH-LOGICAL-c500t-a0fdd79bb48554c74c900f3755d3599f2f765e2904e424dda80c7f0641abf8dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252408/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252408/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,41493,42562,51324,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22009642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Absalan, Forouzan</creatorcontrib><creatorcontrib>Ghannadi, Alireza</creatorcontrib><creatorcontrib>Kazerooni, Marjaneh</creatorcontrib><creatorcontrib>Parifar, Rostami</creatorcontrib><creatorcontrib>Jamalzadeh, Fatemeh</creatorcontrib><creatorcontrib>Amiri, Sahar</creatorcontrib><title>Value of sperm chromatin dispersion test in couples with unexplained recurrent abortion</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Objective
To evaluate and compare standard sperm parameters and sperm chromatin integrity by sperm chromatin dispersion test (SCD) in ejaculates from men whose partners have a history of recurrent pregnancy loss and from control group of fertile men.
Methods
Thirty couples with unexplained recurrent abortion (case group) and 30 fertile couples (control group) referring to Shiraz infertility center were included. Sperm parameters were assessed in semen samples from two groups and then staining with SCD procedure. The results were analyzed by performing ANOVA and Tukey
,
s tests.
Results
In control group, nucleoids with big (65.93 ± 2.35), small (12.4 ± 0.60) and without halo (11.6 ± 0.50) showed significant difference with case group (41.40 ± 1.43), (21.16 ± 1.11) and (23.26 ± 1.10) respectively. In the RPL group spermatozoa with high percentage of abnormal parameters (morphology and motility) was observed (
p
≤ 0.05).
Conclusion
This study strengthens the current literature associating sperm quality with recurrent pregnancy loss, and emphasizes the important of evaluating male factor by tests such as SCD in addition to conventional sperm parameters.</description><subject>Abortion</subject><subject>Abortion, Habitual - genetics</subject><subject>Abortion, Habitual - metabolism</subject><subject>Chromatin</subject><subject>Chromatin - chemistry</subject><subject>Chromatin - metabolism</subject><subject>DNA damage</subject><subject>DNA Fragmentation</subject><subject>Female</subject><subject>Gamete Biology</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscarriage</subject><subject>Morphology</subject><subject>Motility</subject><subject>Nucleoids</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Reproductive Medicine</subject><subject>Semen</subject><subject>Sperm</subject><subject>Sperm Count</subject><subject>Sperm Motility - genetics</subject><subject>Spermatozoa - cytology</subject><subject>Spermatozoa - metabolism</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUmLFjEQhhtRnHH0B3iR4MVTa2XrJBdBBjcY8OJyDOks82XoTtqk2-Xfm-YbxwXEU4qqp96qytt1DzE8xQDiWcUgMe8B414NTPRwqzvFXNBeUAq3Wwxc9sAGedLdq_UKAJQk9G53QkgLB0ZOu08fzbR5lAOqiy8zsoeSZ7PGhFzcMzXmhFZfV9RSNm_L5Cv6GtcD2pL_tkwmJu9Q8XYrxacVmTGXtfXc7-4EM1X_4Po96z68evn-_E1_8e712_MXF73lAGtvIDgn1DgyyTmzglkFEKjg3FGuVCBBDNwTBcwzwpwzEqwIMDBsxiCdpWfd86Puso2zd7btUMyklxJnU77rbKL-s5LiQV_mL5oSThjIJvDkWqDkz1s7VM-xWj9NJvm8Va3IICURoP5PYjYMTEncyMd_kVd5K6n9ww7R5oqABuEjZEuutfhwszQGvdurj_bqZq_e7dV7z6Pfr73p-OlnA8gRqK2ULn35Nfnfqj8A6LGxkw</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Absalan, Forouzan</creator><creator>Ghannadi, Alireza</creator><creator>Kazerooni, Marjaneh</creator><creator>Parifar, Rostami</creator><creator>Jamalzadeh, Fatemeh</creator><creator>Amiri, Sahar</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Value of sperm chromatin dispersion test in couples with unexplained recurrent abortion</title><author>Absalan, Forouzan ; Ghannadi, Alireza ; Kazerooni, Marjaneh ; Parifar, Rostami ; Jamalzadeh, Fatemeh ; Amiri, Sahar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-a0fdd79bb48554c74c900f3755d3599f2f765e2904e424dda80c7f0641abf8dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abortion</topic><topic>Abortion, Habitual - genetics</topic><topic>Abortion, Habitual - metabolism</topic><topic>Chromatin</topic><topic>Chromatin - chemistry</topic><topic>Chromatin - metabolism</topic><topic>DNA damage</topic><topic>DNA Fragmentation</topic><topic>Female</topic><topic>Gamete Biology</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miscarriage</topic><topic>Morphology</topic><topic>Motility</topic><topic>Nucleoids</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Reproductive Medicine</topic><topic>Semen</topic><topic>Sperm</topic><topic>Sperm Count</topic><topic>Sperm Motility - genetics</topic><topic>Spermatozoa - cytology</topic><topic>Spermatozoa - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Absalan, Forouzan</creatorcontrib><creatorcontrib>Ghannadi, Alireza</creatorcontrib><creatorcontrib>Kazerooni, Marjaneh</creatorcontrib><creatorcontrib>Parifar, Rostami</creatorcontrib><creatorcontrib>Jamalzadeh, Fatemeh</creatorcontrib><creatorcontrib>Amiri, Sahar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Absalan, Forouzan</au><au>Ghannadi, Alireza</au><au>Kazerooni, Marjaneh</au><au>Parifar, Rostami</au><au>Jamalzadeh, Fatemeh</au><au>Amiri, Sahar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of sperm chromatin dispersion test in couples with unexplained recurrent abortion</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>29</volume><issue>1</issue><spage>11</spage><epage>14</epage><pages>11-14</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Objective
To evaluate and compare standard sperm parameters and sperm chromatin integrity by sperm chromatin dispersion test (SCD) in ejaculates from men whose partners have a history of recurrent pregnancy loss and from control group of fertile men.
Methods
Thirty couples with unexplained recurrent abortion (case group) and 30 fertile couples (control group) referring to Shiraz infertility center were included. Sperm parameters were assessed in semen samples from two groups and then staining with SCD procedure. The results were analyzed by performing ANOVA and Tukey
,
s tests.
Results
In control group, nucleoids with big (65.93 ± 2.35), small (12.4 ± 0.60) and without halo (11.6 ± 0.50) showed significant difference with case group (41.40 ± 1.43), (21.16 ± 1.11) and (23.26 ± 1.10) respectively. In the RPL group spermatozoa with high percentage of abnormal parameters (morphology and motility) was observed (
p
≤ 0.05).
Conclusion
This study strengthens the current literature associating sperm quality with recurrent pregnancy loss, and emphasizes the important of evaluating male factor by tests such as SCD in addition to conventional sperm parameters.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22009642</pmid><doi>10.1007/s10815-011-9647-0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Abortion Abortion, Habitual - genetics Abortion, Habitual - metabolism Chromatin Chromatin - chemistry Chromatin - metabolism DNA damage DNA Fragmentation Female Gamete Biology Gynecology Human Genetics Humans In vitro fertilization Infertility Male Medicine Medicine & Public Health Miscarriage Morphology Motility Nucleoids Pregnancy Proteins Reproductive Medicine Semen Sperm Sperm Count Sperm Motility - genetics Spermatozoa - cytology Spermatozoa - metabolism |
| title | Value of sperm chromatin dispersion test in couples with unexplained recurrent abortion |
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