Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families
Background: To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein–Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among unaffecte...
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| Veröffentlicht in: | British journal of cancer 2012-01, Vol.106 (1), p.206-209 |
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| creator | Chang, C M Yu, K J Hsu, W L Major, J M Chen, J Y Lou, P J Liu, M Y Diehl, S R Goldstein, A M Chen, C J Hildesheim, A |
| description | Background:
To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein–Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among unaffected relatives from a large NPC family study in Taiwan.
Methods:
Multivariate logistic regression conditioned on family was used to examine the associations between sociodemographic, dietary, lifestyle, and occupational variables and risk of anti-EBV EBNA1 IgA positivity, anti-VCA IgA, and anti-DNase positivity.
Results:
Among 2393 unaffected relatives from 319 multiplex families, 1180 (49.3%) were anti-EBV EBNA1 IgA seropositive. None of the associations with anti-EBNA1 IgA were statistically significant, except for being 31–50 years of age (
vs |
| doi_str_mv | 10.1038/bjc.2011.502 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3251852</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2552442841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c547t-bd7dd798da9c02955ba64b94daeb6ab91fab144d8d7c7a75f189c3258b5221bb3</originalsourceid><addsrcrecordid>eNp9kc9vFCEUx4nR2LV682yIFz04KzCwA5cm282qTRq9qFfyYJgtmxkYYWa1_73UrfVHjCdC3ud9eY8PQk8pWVJSy9dmb5eMULoUhN1DCypqVlHJmvtoQQhpKqIYOUGPct6XqyKyeYhOGCNKMKYW6OsmpuR6mFzGscMQJl9tzz_j7fn7NcUXuzUeY_aTP_jpGsMQww7PAbrO2cm1-EenP5TeLsUBB8hxvIJ0HXYOemwhWR_iAHiY-8mPvfuGOxh8711-jB500Gf35PY8RZ_ebD9u3lWXH95ebNaXlRW8mSrTNm3bKNmCsoQpIQysuFG8BWdWYBTtwFDOW9k2toFGdFQqWzMhTVmPGlOforNj7jibwbXWhSlBr8fkhzKnjuD1n5Xgr_QuHnQJoVKwEvDiNiDFL7PLkx58tq7vIbg4Z60orwmtBS_ky_-SlBAp2YrwuqDP_0L3cU6hfETJq7nktZQFenWEbIo5J9fdTU2JvlGvi3p9o14X9QV_9vumd_BP1wWojkAupWIo_Xr0n4HfARJ-us8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>913484388</pqid></control><display><type>article</type><title>Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><source>PubMed Central</source><creator>Chang, C M ; Yu, K J ; Hsu, W L ; Major, J M ; Chen, J Y ; Lou, P J ; Liu, M Y ; Diehl, S R ; Goldstein, A M ; Chen, C J ; Hildesheim, A</creator><creatorcontrib>Chang, C M ; Yu, K J ; Hsu, W L ; Major, J M ; Chen, J Y ; Lou, P J ; Liu, M Y ; Diehl, S R ; Goldstein, A M ; Chen, C J ; Hildesheim, A</creatorcontrib><description>Background:
To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein–Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among unaffected relatives from a large NPC family study in Taiwan.
Methods:
Multivariate logistic regression conditioned on family was used to examine the associations between sociodemographic, dietary, lifestyle, and occupational variables and risk of anti-EBV EBNA1 IgA positivity, anti-VCA IgA, and anti-DNase positivity.
Results:
Among 2393 unaffected relatives from 319 multiplex families, 1180 (49.3%) were anti-EBV EBNA1 IgA seropositive. None of the associations with anti-EBNA1 IgA were statistically significant, except for being 31–50 years of age (
vs
<30, adjusted ORs 0.51–0.57). For one or more EBV serological markers, there were suggestive associations for older age, GuangDong firm salted fish, betel use, current alcohol use, and male gender.
Conclusion:
Overall, we found little evidence to suggest that non-viral NPC risk factors significantly alter EBV serological patterns, suggesting that non-viral NPC risk factors act through pathways independent of EBV serological responses.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2011.502</identifier><identifier>PMID: 22095229</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Adult ; Alcohol use ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Drug Resistance ; Education ; Enzymes ; Epidemiology ; Epstein-Barr virus ; Epstein-Barr Virus Nuclear Antigens - immunology ; Ethnicity ; Families & family life ; Family ; Female ; Food ; Gender ; Herpesvirus 4, Human - immunology ; Humans ; Immunoglobulin A - blood ; Male ; Medical research ; Middle Aged ; Molecular Medicine ; Nasopharyngeal Neoplasms - immunology ; Nasopharyngeal Neoplasms - pathology ; Oncology ; Questionnaires ; Regression analysis ; Risk factors ; Serology ; Short Communication ; Sociodemographics ; Variables</subject><ispartof>British journal of cancer, 2012-01, Vol.106 (1), p.206-209</ispartof><rights>The Author(s) 2012</rights><rights>Copyright Nature Publishing Group Jan 3, 2012</rights><rights>Copyright © 2012 Cancer Research UK 2012 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-bd7dd798da9c02955ba64b94daeb6ab91fab144d8d7c7a75f189c3258b5221bb3</citedby><cites>FETCH-LOGICAL-c547t-bd7dd798da9c02955ba64b94daeb6ab91fab144d8d7c7a75f189c3258b5221bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251852/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251852/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,41469,42538,51300,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22095229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, C M</creatorcontrib><creatorcontrib>Yu, K J</creatorcontrib><creatorcontrib>Hsu, W L</creatorcontrib><creatorcontrib>Major, J M</creatorcontrib><creatorcontrib>Chen, J Y</creatorcontrib><creatorcontrib>Lou, P J</creatorcontrib><creatorcontrib>Liu, M Y</creatorcontrib><creatorcontrib>Diehl, S R</creatorcontrib><creatorcontrib>Goldstein, A M</creatorcontrib><creatorcontrib>Chen, C J</creatorcontrib><creatorcontrib>Hildesheim, A</creatorcontrib><title>Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein–Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among unaffected relatives from a large NPC family study in Taiwan.
Methods:
Multivariate logistic regression conditioned on family was used to examine the associations between sociodemographic, dietary, lifestyle, and occupational variables and risk of anti-EBV EBNA1 IgA positivity, anti-VCA IgA, and anti-DNase positivity.
Results:
Among 2393 unaffected relatives from 319 multiplex families, 1180 (49.3%) were anti-EBV EBNA1 IgA seropositive. None of the associations with anti-EBNA1 IgA were statistically significant, except for being 31–50 years of age (
vs
<30, adjusted ORs 0.51–0.57). For one or more EBV serological markers, there were suggestive associations for older age, GuangDong firm salted fish, betel use, current alcohol use, and male gender.
Conclusion:
Overall, we found little evidence to suggest that non-viral NPC risk factors significantly alter EBV serological patterns, suggesting that non-viral NPC risk factors act through pathways independent of EBV serological responses.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alcohol use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Education</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Nuclear Antigens - immunology</subject><subject>Ethnicity</subject><subject>Families & family life</subject><subject>Family</subject><subject>Female</subject><subject>Food</subject><subject>Gender</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Nasopharyngeal Neoplasms - immunology</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Oncology</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Serology</subject><subject>Short Communication</subject><subject>Sociodemographics</subject><subject>Variables</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9vFCEUx4nR2LV682yIFz04KzCwA5cm282qTRq9qFfyYJgtmxkYYWa1_73UrfVHjCdC3ud9eY8PQk8pWVJSy9dmb5eMULoUhN1DCypqVlHJmvtoQQhpKqIYOUGPct6XqyKyeYhOGCNKMKYW6OsmpuR6mFzGscMQJl9tzz_j7fn7NcUXuzUeY_aTP_jpGsMQww7PAbrO2cm1-EenP5TeLsUBB8hxvIJ0HXYOemwhWR_iAHiY-8mPvfuGOxh8711-jB500Gf35PY8RZ_ebD9u3lWXH95ebNaXlRW8mSrTNm3bKNmCsoQpIQysuFG8BWdWYBTtwFDOW9k2toFGdFQqWzMhTVmPGlOforNj7jibwbXWhSlBr8fkhzKnjuD1n5Xgr_QuHnQJoVKwEvDiNiDFL7PLkx58tq7vIbg4Z60orwmtBS_ky_-SlBAp2YrwuqDP_0L3cU6hfETJq7nktZQFenWEbIo5J9fdTU2JvlGvi3p9o14X9QV_9vumd_BP1wWojkAupWIo_Xr0n4HfARJ-us8</recordid><startdate>20120103</startdate><enddate>20120103</enddate><creator>Chang, C M</creator><creator>Yu, K J</creator><creator>Hsu, W L</creator><creator>Major, J M</creator><creator>Chen, J Y</creator><creator>Lou, P J</creator><creator>Liu, M Y</creator><creator>Diehl, S R</creator><creator>Goldstein, A M</creator><creator>Chen, C J</creator><creator>Hildesheim, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7T5</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120103</creationdate><title>Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families</title><author>Chang, C M ; Yu, K J ; Hsu, W L ; Major, J M ; Chen, J Y ; Lou, P J ; Liu, M Y ; Diehl, S R ; Goldstein, A M ; Chen, C J ; Hildesheim, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-bd7dd798da9c02955ba64b94daeb6ab91fab144d8d7c7a75f189c3258b5221bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alcohol use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Education</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Nuclear Antigens - immunology</topic><topic>Ethnicity</topic><topic>Families & family life</topic><topic>Family</topic><topic>Female</topic><topic>Food</topic><topic>Gender</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Humans</topic><topic>Immunoglobulin A - blood</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Nasopharyngeal Neoplasms - immunology</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Oncology</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Serology</topic><topic>Short Communication</topic><topic>Sociodemographics</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, C M</creatorcontrib><creatorcontrib>Yu, K J</creatorcontrib><creatorcontrib>Hsu, W L</creatorcontrib><creatorcontrib>Major, J M</creatorcontrib><creatorcontrib>Chen, J Y</creatorcontrib><creatorcontrib>Lou, P J</creatorcontrib><creatorcontrib>Liu, M Y</creatorcontrib><creatorcontrib>Diehl, S R</creatorcontrib><creatorcontrib>Goldstein, A M</creatorcontrib><creatorcontrib>Chen, C J</creatorcontrib><creatorcontrib>Hildesheim, A</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Immunology Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, C M</au><au>Yu, K J</au><au>Hsu, W L</au><au>Major, J M</au><au>Chen, J Y</au><au>Lou, P J</au><au>Liu, M Y</au><au>Diehl, S R</au><au>Goldstein, A M</au><au>Chen, C J</au><au>Hildesheim, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2012-01-03</date><risdate>2012</risdate><volume>106</volume><issue>1</issue><spage>206</spage><epage>209</epage><pages>206-209</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein–Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among unaffected relatives from a large NPC family study in Taiwan.
Methods:
Multivariate logistic regression conditioned on family was used to examine the associations between sociodemographic, dietary, lifestyle, and occupational variables and risk of anti-EBV EBNA1 IgA positivity, anti-VCA IgA, and anti-DNase positivity.
Results:
Among 2393 unaffected relatives from 319 multiplex families, 1180 (49.3%) were anti-EBV EBNA1 IgA seropositive. None of the associations with anti-EBNA1 IgA were statistically significant, except for being 31–50 years of age (
vs
<30, adjusted ORs 0.51–0.57). For one or more EBV serological markers, there were suggestive associations for older age, GuangDong firm salted fish, betel use, current alcohol use, and male gender.
Conclusion:
Overall, we found little evidence to suggest that non-viral NPC risk factors significantly alter EBV serological patterns, suggesting that non-viral NPC risk factors act through pathways independent of EBV serological responses.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22095229</pmid><doi>10.1038/bjc.2011.502</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Nature Journals Online; PubMed Central |
| subjects | Adolescent Adult Alcohol use Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Education Enzymes Epidemiology Epstein-Barr virus Epstein-Barr Virus Nuclear Antigens - immunology Ethnicity Families & family life Family Female Food Gender Herpesvirus 4, Human - immunology Humans Immunoglobulin A - blood Male Medical research Middle Aged Molecular Medicine Nasopharyngeal Neoplasms - immunology Nasopharyngeal Neoplasms - pathology Oncology Questionnaires Regression analysis Risk factors Serology Short Communication Sociodemographics Variables |
| title | Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families |
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