Predictive role of XRCC5/XRCC6 genotypes in digestive system cancers
Cancers are a worldwide concern;oral,esophageal and gastrointestinal cancers represent important causes of cancer-related mortality and contribute to a signif icant burden of human health.The DNA repair systems are the genome caretakers,playing a critical role in the initiation and progression of ca...
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| Veröffentlicht in: | World journal of gastrointestinal oncology 2011-12, Vol.3 (12), p.175-181 |
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| container_end_page | 181 |
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| container_issue | 12 |
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| container_title | World journal of gastrointestinal oncology |
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| creator | Yang, Mei-Due Tsai, Chia-Wen Chang, Wen-Shin Tsou, Yung-An Wu, Cheng-Nan Bau, Da-Tian |
| description | Cancers are a worldwide concern;oral,esophageal and gastrointestinal cancers represent important causes of cancer-related mortality and contribute to a signif icant burden of human health.The DNA repair systems are the genome caretakers,playing a critical role in the initiation and progression of cancers.However,the association between the genomic variations of DNA repair genes and cancer susceptibility is not well understood.This review focuses on the polymorphic genotypes of the non-homologous end-joining DNA repair system,highlighting the role of two genes of this pathway,XRCC5 and XRCC6,in the susceptibility to digestive system cancers and discussing their potential contributions to personalized medicine. |
| doi_str_mv | 10.4251/wjgo.v3.i12.175 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1948-5204 |
| ispartof | World journal of gastrointestinal oncology, 2011-12, Vol.3 (12), p.175-181 |
| issn | 1948-5204 1948-5204 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3251741 |
| source | Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | cancer Colorectal Esophageal Gastrointestinal Oral Polymorphism Review XRCC5 XRCC6 |
| title | Predictive role of XRCC5/XRCC6 genotypes in digestive system cancers |
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