The blood-testis barrier and its implications for male contraception

The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian body. It divides the seminiferous epithelium into the basal and the apical (adluminal) compartments. Meiosis I and II, spermiogenesis, and spermiation all take place in a specialized microenvironment behind...

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Veröffentlicht in:	Pharmacological reviews 2012-01, Vol.64 (1), p.16-64
Hauptverfasser:	Cheng, C Yan, Mruk, Dolores D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Testis Barrier - immunology Blood-Testis Barrier - metabolism Blood-Testis Barrier - physiology Blood-Testis Barrier - ultrastructure Contraceptive Agents, Male - administration & dosage Contraceptive Agents, Male - pharmacokinetics Drug Delivery Systems Gonadal Steroid Hormones - metabolism Humans Male Models, Biological Review Sertoli Cells - drug effects Sertoli Cells - immunology Sertoli Cells - metabolism Sertoli Cells - ultrastructure Spermatogenesis - drug effects
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