Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice

Regenerative medicine holds the promise of restoring cells and tissues that are destroyed in human disease, including degenerative eye disorders. However, development of this approach in the eye has been limited by a lack of animal models that show robust regeneration of ocular tissue. Here, we test...

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Veröffentlicht in:	Experimental eye research 2011-12, Vol.93 (6), p.862-872
Hauptverfasser:	Xia, Huiming, Krebs, Mark P., Kaushal, Shalesh, Scott, Edward W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animal models Animals Body weight Carrier Proteins - metabolism Cell Proliferation Cell Shape cis-trans-Isomerases Disease Models, Animal Electroretinography Evoked Potentials, Visual Eye Eye disorders Eye Proteins - metabolism Green Fluorescent Proteins - biosynthesis Green Fluorescent Proteins - genetics healer mice Immunohistochemistry Injuries Iodates Macular degeneration Macular Degeneration - chemically induced Macular Degeneration - genetics Macular Degeneration - metabolism Macular Degeneration - pathology Macular Degeneration - physiopathology Mice Mice, Inbred AKR Mice, Inbred C57BL Mice, Transgenic Microscopy, Fluorescence Molecular modelling MRL/MpJ phalloidin Photic Stimulation Preservation Recovery of Function Regeneration regenerative medicine Retina retinal pigment epithelium Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Retinal Pigment Epithelium - physiopathology Sodium sodium iodate Time Factors Titration Wound healing
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