Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus of young (4- to 6-month-old) PS1 M146L /APP 751SL mice model, as the initial degen...

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Veröffentlicht in:	Acta neuropathologica 2012-01, Vol.123 (1), p.53-70
Hauptverfasser:	Sanchez-Varo, Raquel, Trujillo-Estrada, Laura, Sanchez-Mejias, Elisabeth, Torres, Manuel, Baglietto-Vargas, David, Moreno-Gonzalez, Ines, De Castro, Vanessa, Jimenez, Sebastian, Ruano, Diego, Vizuete, Marisa, Davila, Jose Carlos, Garcia-Verdugo, Jose Manuel, Jimenez, Antonio Jesus, Vitorica, Javier, Gutierrez, Antonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Amyloid beta-Protein Precursor - metabolism Animal models Animals Autophagy Axonal transport Axonogenesis Axons - ultrastructure beta -Amyloid Brain Cytoplasmic Vesicles - ultrastructure Cytoskeleton Deposits Disease Models, Animal Dynein Dystrophy Hippocampus Hippocampus - metabolism Hippocampus - ultrastructure Medicine Medicine & Public Health Mice Mice, Transgenic Microscopy, Immunoelectron Morphology Neurites - ultrastructure Neurodegenerative diseases Neurons Neurons - metabolism Neurophysiology Neurosciences Oligomers Original Paper Pathology Peptides Phagocytosis Phagosomes Plaque, Amyloid - metabolism Plaque, Amyloid - ultrastructure Plaques Presynaptic Terminals - ultrastructure Proteins Rods Synaptosomes Tau protein Transgenic animals Vesicles
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