Toward a Systems Biology Perspective on Enzyme Evolution

Large superfamilies of enzymes derived from a common progenitor have emerged by duplication and divergence of genes encoding metabolic enzymes. Division of the functions of early generalist enzymes enhanced catalytic power and control over metabolic fluxes. Later, novel enzymes evolved from ineffici...

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Veröffentlicht in:	The Journal of biological chemistry 2012-01, Vol.287 (1), p.3-10
1. Verfasser:	Copley, Shelley D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzymes Enzymes - genetics Enzymes - metabolism Epistasis, Genetic Evolution Evolution, Molecular Gene Amplification Gene Knock-out Metabolic Network Metabolism Minireviews Molecular Evolution Substrate Specificity Systems Biology Systems Biology - methods
Online-Zugang:	Volltext
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