Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells

The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft. In addition, it is the site of action of antidepressants (which block the transporter) and of amphetamines (which induce substrate efflux). The interaction energies involved in binding of suc...

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Veröffentlicht in:	The Journal of biological chemistry 2012-01, Vol.287 (1), p.105-113
Hauptverfasser:	Wildling, Linda, Rankl, Christian, Haselgrübler, Thomas, Gruber, Hermann J., Holy, Marion, Newman, Amy Hauck, Zou, Mu-Fa, Zhu, Rong, Freissmuth, Michael, Sitte, Harald H., Hinterdorfer, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atomic Force Microscopy Binding Reaction Binding Sites Cell Survival CHO Cells Cricetinae Cricetulus Force Spectroscopy HEK293 Cells Humans Kinetics Ligands MFZ2-12 Microscopy, Atomic Force Molecular Biophysics Molecular Docking Molecular Imaging Protein Binding Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin Transporters Serotonin Uptake Inhibitors - metabolism Spectroscopy Thermodynamics Tropanes - metabolism
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