Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction
Abstract Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy thro...
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| Veröffentlicht in: | Placenta (Eastbourne) 2012-01, Vol.33 (1), p.77-80 |
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| creator | Collier, A.C Milam, K.A Rougée, L.R.A Sugawara, A Yamauchi, Y Ward, M.A |
| description | Abstract Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1 , 1a2 , 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone ( 1a1 ) and cholesterol ( 1a2 , 1a6 ) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes. |
| doi_str_mv | 10.1016/j.placenta.2011.11.002 |
| format | Article |
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Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1 , 1a2 , 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone ( 1a1 ) and cholesterol ( 1a2 , 1a6 ) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2011.11.002</identifier><identifier>PMID: 22115498</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Assisted reproduction ; Biological and medical sciences ; Cholesterol - metabolism ; Crosses, Genetic ; Detoxification ; Disease Models, Animal ; Embryology: invertebrates and vertebrates. Teratology ; Endocrinology ; Female ; Fertilization in Vitro ; Fundamental and applied biological sciences. Psychology ; Glucuronosyltransferase - genetics ; Glucuronosyltransferase - metabolism ; Infertility, Female - enzymology ; Infertility, Female - metabolism ; Infertility, Female - therapy ; Internal Medicine ; Isoenzymes - genetics ; Isoenzymes - metabolism ; Liver - embryology ; Liver - enzymology ; Liver - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Obstetrics and Gynecology ; Placenta ; Placenta - enzymology ; Placenta - metabolism ; Pregnancy ; Pregnancy Proteins - genetics ; Pregnancy Proteins - metabolism ; Progesterone - metabolism ; Sperm Injections, Intracytoplasmic ; Up-Regulation</subject><ispartof>Placenta (Eastbourne), 2012-01, Vol.33 (1), p.77-80</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><rights>2011 Elsevier Ltd. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-1fa99c3f64de95d849dd7679e77a798a2dc92905860901563b35ddec39282da63</citedby><cites>FETCH-LOGICAL-c555t-1fa99c3f64de95d849dd7679e77a798a2dc92905860901563b35ddec39282da63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143400411005340$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25372873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22115498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collier, A.C</creatorcontrib><creatorcontrib>Milam, K.A</creatorcontrib><creatorcontrib>Rougée, L.R.A</creatorcontrib><creatorcontrib>Sugawara, A</creatorcontrib><creatorcontrib>Yamauchi, Y</creatorcontrib><creatorcontrib>Ward, M.A</creatorcontrib><title>Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Abstract Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1 , 1a2 , 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone ( 1a1 ) and cholesterol ( 1a2 , 1a6 ) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.</description><subject>Animals</subject><subject>Assisted reproduction</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - metabolism</subject><subject>Crosses, Genetic</subject><subject>Detoxification</subject><subject>Disease Models, Animal</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucuronosyltransferase - genetics</subject><subject>Glucuronosyltransferase - metabolism</subject><subject>Infertility, Female - enzymology</subject><subject>Infertility, Female - metabolism</subject><subject>Infertility, Female - therapy</subject><subject>Internal Medicine</subject><subject>Isoenzymes - genetics</subject><subject>Isoenzymes - metabolism</subject><subject>Liver - embryology</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta</subject><subject>Placenta - enzymology</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy Proteins - genetics</subject><subject>Pregnancy Proteins - metabolism</subject><subject>Progesterone - metabolism</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>Up-Regulation</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoMo7rj6F5ZcxFOP-ezuXBZl8QsWPOicQzapHjOmkzHpHth_b9qZWT8uQkEC9dRbRb2F0BUla0po-3q33gdjIU5mzQil6xqEsEdoRSVnDaeEPUYrQgVvBCHiAj0rZUcIUYKyp-iCMUqlUP0Kuc0-w3YOZvIp4jTgzXaiBm8hQsE-4nOXgk10eIDJBBz8AfKvrMHjnH0EPCYHYSk3pfgygcMZ9jm52S66z9GTwYQCL07vJdq8f_f15mNz-_nDp5u3t42VUk4NHYxSlg-tcKCk64Vyrms7BV1nOtUb5qxiisi-JYpQ2fI7Lp0DyxXrmTMtv0TXR939fDeCWwbPJuh99qPJ9zoZr__ORP9Nb9NBcyaqYl8FXp0EcvoxQ5n06IuFEEyENBetKOe0Z0JUsj2SNqdSMgwPXSjRi0N6p8-704tDukZ1qBZe_TnjQ9nZkgq8PAGmWBOGbKL15Tcnecf6jlfuzZGDutGDh6yL9RAtOJ_BTtol__9Zrv-RsMFHX7t-h3souzTnWP3SVBemif6y3NNyTpQSIuuP_wRFHMiG</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Collier, A.C</creator><creator>Milam, K.A</creator><creator>Rougée, L.R.A</creator><creator>Sugawara, A</creator><creator>Yamauchi, Y</creator><creator>Ward, M.A</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction</title><author>Collier, A.C ; Milam, K.A ; Rougée, L.R.A ; Sugawara, A ; Yamauchi, Y ; Ward, M.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-1fa99c3f64de95d849dd7679e77a798a2dc92905860901563b35ddec39282da63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Assisted reproduction</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - metabolism</topic><topic>Crosses, Genetic</topic><topic>Detoxification</topic><topic>Disease Models, Animal</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucuronosyltransferase - genetics</topic><topic>Glucuronosyltransferase - metabolism</topic><topic>Infertility, Female - enzymology</topic><topic>Infertility, Female - metabolism</topic><topic>Infertility, Female - therapy</topic><topic>Internal Medicine</topic><topic>Isoenzymes - genetics</topic><topic>Isoenzymes - metabolism</topic><topic>Liver - embryology</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta</topic><topic>Placenta - enzymology</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy Proteins - genetics</topic><topic>Pregnancy Proteins - metabolism</topic><topic>Progesterone - metabolism</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collier, A.C</creatorcontrib><creatorcontrib>Milam, K.A</creatorcontrib><creatorcontrib>Rougée, L.R.A</creatorcontrib><creatorcontrib>Sugawara, A</creatorcontrib><creatorcontrib>Yamauchi, Y</creatorcontrib><creatorcontrib>Ward, M.A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collier, A.C</au><au>Milam, K.A</au><au>Rougée, L.R.A</au><au>Sugawara, A</au><au>Yamauchi, Y</au><au>Ward, M.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>33</volume><issue>1</issue><spage>77</spage><epage>80</epage><pages>77-80</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><abstract>Abstract Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1 , 1a2 , 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone ( 1a1 ) and cholesterol ( 1a2 , 1a6 ) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>22115498</pmid><doi>10.1016/j.placenta.2011.11.002</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Placenta (Eastbourne), 2012-01, Vol.33 (1), p.77-80 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Assisted reproduction Biological and medical sciences Cholesterol - metabolism Crosses, Genetic Detoxification Disease Models, Animal Embryology: invertebrates and vertebrates. Teratology Endocrinology Female Fertilization in Vitro Fundamental and applied biological sciences. Psychology Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism Infertility, Female - enzymology Infertility, Female - metabolism Infertility, Female - therapy Internal Medicine Isoenzymes - genetics Isoenzymes - metabolism Liver - embryology Liver - enzymology Liver - metabolism Mice Mice, Inbred C57BL Mice, Inbred DBA Obstetrics and Gynecology Placenta Placenta - enzymology Placenta - metabolism Pregnancy Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Progesterone - metabolism Sperm Injections, Intracytoplasmic Up-Regulation |
| title | Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction |
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