A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold

Histone deacetylases (HDACs) are enzymes involved in many important biological functions. They have been linked to a variety of cancers, psychiatric disorders, and other diseases. Since small molecules can serve as probes to study the relevant biological roles of HDACs, novel scaffolds are necessary...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-07, Vol.21 (14), p.4164-4169
Hauptverfasser:	Kemp, Melissa M., Wang, Qiu, Fuller, Jason H., West, Nathan, Martinez, Nicole M., Morse, Elizabeth M., Weïwer, Michel, Schreiber, Stuart L., Bradner, James E., Koehler, Angela N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Analytical, structural and metabolic biochemistry Biological and medical sciences drugs Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Histone deacetylase Histone Deacetylase Inhibitors - chemical synthesis Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - chemistry Histone Deacetylases - metabolism Humans Hydrolases Hydroxy-pyrimidine Medical sciences Miscellaneous neoplasms Non-selective inhibitor Pharmacology. Drug treatments Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology SAR studies screening Structure-Activity Relationship structure-activity relationships
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