Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

The p53-family member TAp73 is a transcription factor that plays a key role in many biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific binding sites on the miR-34a promoter. Expression of miR-34a is modulated in par...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-12, Vol.108 (52), p.21093-21098
Hauptverfasser:	Agostini, Massimiliano, Tucci, Paola, Killick, Richard, Candi, Eleonora, Sayan, Berna S., di val Cervo, Pia Rivetti, Nicotera, Pierluigi, McKeon, Frank, Knight, Richard A., Mak, Tak W., Melino, Gerry
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Alzheimers disease Animals Apoptosis Binding sites Biological Sciences Blotting, Western Brain Cell Differentiation - physiology Cell lines Cerebellum Cerebral Cortex - metabolism Cerebral Cortex - physiology Chromatin Immunoprecipitation Computational Biology Cortex Data processing Differentiation Gene expression Gene expression regulation Gene Expression Regulation - genetics Gene Expression Regulation - physiology Hippocampus Hippocampus - metabolism Humans Laser Capture Microdissection Messenger RNA Mice Mice, Knockout MicroRNAs - metabolism miRNA Neuroblastoma Neuroblastoma cells Neurodegenerative diseases Neurons Neurons - cytology Nuclear Proteins - genetics Nuclear Proteins - metabolism Promoter Regions, Genetic - genetics Promoters Proteins Real-Time Polymerase Chain Reaction Rodents Synaptogenesis Synaptotagmin Synaptotagmin I - metabolism syntaxin 1 Transcription Transcription factors Up regulation
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