Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Glioblastoma multiforme (GBM) is the most common and lethal of all gliomas. The current standard of care includes surgery followed by concomitant radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ). O⁶-methylguanine-DNA methyltransferase (MGMT) repairs the most cytotoxic of l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2012-01, Vol.122 (1), p.253-266
Hauptverfasser:	Agnihotri, Sameer, Gajadhar, Aaron S, Ternamian, Christian, Gorlia, Thierry, Diefes, Kristin L, Mischel, Paul S, Kelly, Joanna, McGown, Gail, Thorncroft, Mary, Carlson, Brett L, Sarkaria, Jann N, Margison, Geoffrey P, Aldape, Kenneth, Hawkins, Cynthia, Hegi, Monika, Guha, Abhijit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - pharmacology Biomedical research Brain cancer Care and treatment Cell Line, Tumor Chemotherapy Cytotoxicity Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Diagnosis DNA damage DNA Glycosylases - antagonists & inhibitors DNA Glycosylases - genetics DNA Glycosylases - metabolism DNA methylation DNA Modification Methylases - antagonists & inhibitors DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA polymerase DNA Repair DNA Repair Enzymes - antagonists & inhibitors DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism Drug Resistance, Neoplasm - genetics Enzymes Gene Expression Gene Knockdown Techniques Genomes Glioblastoma - drug therapy Glioblastoma - enzymology Glioblastoma multiforme Health aspects Humans Methylation Mice Mice, Inbred NOD Mice, SCID Mutation Patient outcomes Proteins Radiation Radiotherapy RNA, Small Interfering - genetics Surgery Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!