Acoustic characterization of echogenic liposomes: Frequency-dependent attenuation and backscatter
Ultrasound contrast agents (UCAs) are used clinically to aid detection and diagnosis of abnormal blood flow or perfusion. Characterization of UCAs can aid in the optimization of ultrasound parameters for enhanced image contrast. In this study echogenic liposomes (ELIPs) were characterized acoustical...
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| Veröffentlicht in: | The Journal of the Acoustical Society of America 2011-11, Vol.130 (5), p.3472-3481 |
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| creator | Kopechek, Jonathan A. Haworth, Kevin J. Raymond, Jason L. Douglas Mast, T. Perrin, Stephen R. Klegerman, Melvin E. Huang, Shaoling Porter, Tyrone M. McPherson, David D. Holland, Christy K. |
| description | Ultrasound contrast agents (UCAs) are used clinically to aid detection and diagnosis of abnormal blood flow or perfusion. Characterization of UCAs can aid in the optimization of ultrasound parameters for enhanced image contrast. In this study echogenic liposomes (ELIPs) were characterized acoustically by measuring the frequency-dependent attenuation and backscatter coefficients at frequencies between 3 and 30 MHz using a broadband pulse-echo technique. The experimental methods were initially validated by comparing the attenuation and backscatter coefficients measured from 50-
μ
m and 100-
μ
m polystyrene microspheres with theoretical values. The size distribution of the ELIPs was measured and found to be polydisperse, ranging in size from 40 nm to 6 μm in diameter, with the highest number observed at 65 nm. The ELIP attenuation coefficients ranged from 3.7±1.0 to 8.0±3.3 dB/cm between 3 and 25 MHz. The backscatter coefficients were 0.011±0.006 (cm str)
−1
between 6 and 9 MHz and 0.023±0.006 (cm str)
−1
between 13 and 30 MHz. The measured scattering-to-attenuation ratio ranged from 8% to 22% between 6 and 25 MHz. Thus ELIPs can provide enhanced contrast over a broad range of frequencies and the scattering properties are suitable for various ultrasound imaging applications including diagnostic and intravascular ultrasound. |
| doi_str_mv | 10.1121/1.3626124 |
| format | Article |
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μ
m and 100-
μ
m polystyrene microspheres with theoretical values. The size distribution of the ELIPs was measured and found to be polydisperse, ranging in size from 40 nm to 6 μm in diameter, with the highest number observed at 65 nm. The ELIP attenuation coefficients ranged from 3.7±1.0 to 8.0±3.3 dB/cm between 3 and 25 MHz. The backscatter coefficients were 0.011±0.006 (cm str)
−1
between 6 and 9 MHz and 0.023±0.006 (cm str)
−1
between 13 and 30 MHz. The measured scattering-to-attenuation ratio ranged from 8% to 22% between 6 and 25 MHz. Thus ELIPs can provide enhanced contrast over a broad range of frequencies and the scattering properties are suitable for various ultrasound imaging applications including diagnostic and intravascular ultrasound.</description><identifier>ISSN: 0001-4966</identifier><identifier>EISSN: 1520-8524</identifier><identifier>DOI: 10.1121/1.3626124</identifier><identifier>PMID: 22088022</identifier><identifier>CODEN: JASMAN</identifier><language>eng</language><publisher>United States: Acoustical Society of America</publisher><subject>Acoustics ; Attenuation ; Backscattering ; Broadband ; Contrast agents ; Contrast Media ; Elasticity ; Imaging ; Liposomes ; Microspheres ; Models, Theoretical ; Part 2 Special Issue on the Acoustics of Bubbles and Cavitation ; Particle Size ; Polystyrenes ; Pressure ; Reproducibility of Results ; Scattering, Radiation ; Signal Processing, Computer-Assisted ; Transducers, Pressure ; Ultrasonics - instrumentation ; Ultrasonography, Interventional ; Ultrasound</subject><ispartof>The Journal of the Acoustical Society of America, 2011-11, Vol.130 (5), p.3472-3481</ispartof><rights>2011 Acoustical Society of America</rights><rights>Copyright © 2011 Acoustical Society of America 2011 Acoustical Society of America</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-75c8d73b48017a3de67840c7b46c5e61b4e3c432dbd2568d7d97bb9319d7efab3</citedby><cites>FETCH-LOGICAL-c462t-75c8d73b48017a3de67840c7b46c5e61b4e3c432dbd2568d7d97bb9319d7efab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>207,208,230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22088022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kopechek, Jonathan A.</creatorcontrib><creatorcontrib>Haworth, Kevin J.</creatorcontrib><creatorcontrib>Raymond, Jason L.</creatorcontrib><creatorcontrib>Douglas Mast, T.</creatorcontrib><creatorcontrib>Perrin, Stephen R.</creatorcontrib><creatorcontrib>Klegerman, Melvin E.</creatorcontrib><creatorcontrib>Huang, Shaoling</creatorcontrib><creatorcontrib>Porter, Tyrone M.</creatorcontrib><creatorcontrib>McPherson, David D.</creatorcontrib><creatorcontrib>Holland, Christy K.</creatorcontrib><title>Acoustic characterization of echogenic liposomes: Frequency-dependent attenuation and backscatter</title><title>The Journal of the Acoustical Society of America</title><addtitle>J Acoust Soc Am</addtitle><description>Ultrasound contrast agents (UCAs) are used clinically to aid detection and diagnosis of abnormal blood flow or perfusion. Characterization of UCAs can aid in the optimization of ultrasound parameters for enhanced image contrast. In this study echogenic liposomes (ELIPs) were characterized acoustically by measuring the frequency-dependent attenuation and backscatter coefficients at frequencies between 3 and 30 MHz using a broadband pulse-echo technique. The experimental methods were initially validated by comparing the attenuation and backscatter coefficients measured from 50-
μ
m and 100-
μ
m polystyrene microspheres with theoretical values. The size distribution of the ELIPs was measured and found to be polydisperse, ranging in size from 40 nm to 6 μm in diameter, with the highest number observed at 65 nm. The ELIP attenuation coefficients ranged from 3.7±1.0 to 8.0±3.3 dB/cm between 3 and 25 MHz. The backscatter coefficients were 0.011±0.006 (cm str)
−1
between 6 and 9 MHz and 0.023±0.006 (cm str)
−1
between 13 and 30 MHz. The measured scattering-to-attenuation ratio ranged from 8% to 22% between 6 and 25 MHz. Thus ELIPs can provide enhanced contrast over a broad range of frequencies and the scattering properties are suitable for various ultrasound imaging applications including diagnostic and intravascular ultrasound.</description><subject>Acoustics</subject><subject>Attenuation</subject><subject>Backscattering</subject><subject>Broadband</subject><subject>Contrast agents</subject><subject>Contrast Media</subject><subject>Elasticity</subject><subject>Imaging</subject><subject>Liposomes</subject><subject>Microspheres</subject><subject>Models, Theoretical</subject><subject>Part 2 Special Issue on the Acoustics of Bubbles and Cavitation</subject><subject>Particle Size</subject><subject>Polystyrenes</subject><subject>Pressure</subject><subject>Reproducibility of Results</subject><subject>Scattering, Radiation</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Transducers, Pressure</subject><subject>Ultrasonics - instrumentation</subject><subject>Ultrasonography, Interventional</subject><subject>Ultrasound</subject><issn>0001-4966</issn><issn>1520-8524</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOHDEQRa0IFAaSRX4g6h1h0cSvdndnEQmh8JCQsknWll2uYQw99sT2RCJfH8MMBBZhZdl1fKtuXUI-MHrMGGef2bFQXDEu35AZ6zhth47LHTKjlLJWjkrtkf2cb-q1G8T4luxxToeBcj4j5gTiOhcPDSxMMlAw-T-m-BiaOG8QFvEaQ61OfhVzXGL-0pwl_LXGAHetwxUGh6E0phQM680_E1xjDdxmuH9N78ju3EwZ32_PA_Lz7NuP04v26vv55enJVQtS8dL2HQyuF1YOlPVGOFT9ICn0ViroUDErUYAU3FnHO1VRN_bWjoKNrse5seKAfN3ortZ2iQ7qWMlMepX80qQ7HY3XLyvBL_R1_K0Frz1VXwUOtwIpVoO56KXPgNNkAtYd6ZF2lZJUVvLTqySjrO5XqQfRow0KKeaccP40EKP6PjzN9Da8yn587uCJfEzrn8UMvjws-_9qj7nqZ7mKv1N4rEo</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>Kopechek, Jonathan A.</creator><creator>Haworth, Kevin J.</creator><creator>Raymond, Jason L.</creator><creator>Douglas Mast, T.</creator><creator>Perrin, Stephen R.</creator><creator>Klegerman, Melvin E.</creator><creator>Huang, Shaoling</creator><creator>Porter, Tyrone M.</creator><creator>McPherson, David D.</creator><creator>Holland, Christy K.</creator><general>Acoustical Society of America</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201111</creationdate><title>Acoustic characterization of echogenic liposomes: Frequency-dependent attenuation and backscatter</title><author>Kopechek, Jonathan A. ; Haworth, Kevin J. ; Raymond, Jason L. ; Douglas Mast, T. ; Perrin, Stephen R. ; Klegerman, Melvin E. ; Huang, Shaoling ; Porter, Tyrone M. ; McPherson, David D. ; Holland, Christy K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-75c8d73b48017a3de67840c7b46c5e61b4e3c432dbd2568d7d97bb9319d7efab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acoustics</topic><topic>Attenuation</topic><topic>Backscattering</topic><topic>Broadband</topic><topic>Contrast agents</topic><topic>Contrast Media</topic><topic>Elasticity</topic><topic>Imaging</topic><topic>Liposomes</topic><topic>Microspheres</topic><topic>Models, Theoretical</topic><topic>Part 2 Special Issue on the Acoustics of Bubbles and Cavitation</topic><topic>Particle Size</topic><topic>Polystyrenes</topic><topic>Pressure</topic><topic>Reproducibility of Results</topic><topic>Scattering, Radiation</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Transducers, Pressure</topic><topic>Ultrasonics - instrumentation</topic><topic>Ultrasonography, Interventional</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kopechek, Jonathan A.</creatorcontrib><creatorcontrib>Haworth, Kevin J.</creatorcontrib><creatorcontrib>Raymond, Jason L.</creatorcontrib><creatorcontrib>Douglas Mast, T.</creatorcontrib><creatorcontrib>Perrin, Stephen R.</creatorcontrib><creatorcontrib>Klegerman, Melvin E.</creatorcontrib><creatorcontrib>Huang, Shaoling</creatorcontrib><creatorcontrib>Porter, Tyrone M.</creatorcontrib><creatorcontrib>McPherson, David D.</creatorcontrib><creatorcontrib>Holland, Christy K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of the Acoustical Society of America</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kopechek, Jonathan A.</au><au>Haworth, Kevin J.</au><au>Raymond, Jason L.</au><au>Douglas Mast, T.</au><au>Perrin, Stephen R.</au><au>Klegerman, Melvin E.</au><au>Huang, Shaoling</au><au>Porter, Tyrone M.</au><au>McPherson, David D.</au><au>Holland, Christy K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acoustic characterization of echogenic liposomes: Frequency-dependent attenuation and backscatter</atitle><jtitle>The Journal of the Acoustical Society of America</jtitle><addtitle>J Acoust Soc Am</addtitle><date>2011-11</date><risdate>2011</risdate><volume>130</volume><issue>5</issue><spage>3472</spage><epage>3481</epage><pages>3472-3481</pages><issn>0001-4966</issn><eissn>1520-8524</eissn><coden>JASMAN</coden><abstract>Ultrasound contrast agents (UCAs) are used clinically to aid detection and diagnosis of abnormal blood flow or perfusion. Characterization of UCAs can aid in the optimization of ultrasound parameters for enhanced image contrast. In this study echogenic liposomes (ELIPs) were characterized acoustically by measuring the frequency-dependent attenuation and backscatter coefficients at frequencies between 3 and 30 MHz using a broadband pulse-echo technique. The experimental methods were initially validated by comparing the attenuation and backscatter coefficients measured from 50-
μ
m and 100-
μ
m polystyrene microspheres with theoretical values. The size distribution of the ELIPs was measured and found to be polydisperse, ranging in size from 40 nm to 6 μm in diameter, with the highest number observed at 65 nm. The ELIP attenuation coefficients ranged from 3.7±1.0 to 8.0±3.3 dB/cm between 3 and 25 MHz. The backscatter coefficients were 0.011±0.006 (cm str)
−1
between 6 and 9 MHz and 0.023±0.006 (cm str)
−1
between 13 and 30 MHz. The measured scattering-to-attenuation ratio ranged from 8% to 22% between 6 and 25 MHz. Thus ELIPs can provide enhanced contrast over a broad range of frequencies and the scattering properties are suitable for various ultrasound imaging applications including diagnostic and intravascular ultrasound.</abstract><cop>United States</cop><pub>Acoustical Society of America</pub><pmid>22088022</pmid><doi>10.1121/1.3626124</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of the Acoustical Society of America, 2011-11, Vol.130 (5), p.3472-3481 |
| issn | 0001-4966 1520-8524 |
| language | eng |
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| source | MEDLINE; American Institute of Physics (AIP) Journals; Alma/SFX Local Collection; AIP Acoustical Society of America |
| subjects | Acoustics Attenuation Backscattering Broadband Contrast agents Contrast Media Elasticity Imaging Liposomes Microspheres Models, Theoretical Part 2 Special Issue on the Acoustics of Bubbles and Cavitation Particle Size Polystyrenes Pressure Reproducibility of Results Scattering, Radiation Signal Processing, Computer-Assisted Transducers, Pressure Ultrasonics - instrumentation Ultrasonography, Interventional Ultrasound |
| title | Acoustic characterization of echogenic liposomes: Frequency-dependent attenuation and backscatter |
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