Pharmacologic Uncoupling of Angiogenesis and Inflammation during Initiation of Pathological Corneal Neovascularization

Pathological neovascularization occurs when a balance of pro- and anti-angiogenic factors is disrupted, accompanied by an amplifying inflammatory cascade. However, the interdependence of these responses and the mechanism triggering the initial angiogenic switch have remained unclear. We present data...

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Veröffentlicht in:	The Journal of biological chemistry 2011-12, Vol.286 (52), p.44965-44975
Hauptverfasser:	Sivak, Jeremy M., Ostriker, Allison C., Woolfenden, Amber, Demirs, John, Cepeda, Rosemarie, Long, Debby, Anderson, Karen, Jaffee, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Cornea Cornea - metabolism Cornea - pathology Corneal Neovascularization - drug therapy Corneal Neovascularization - metabolism Corneal Neovascularization - pathology Epithelium Epithelium - metabolism Epithelium - pathology Female Inflammation Macrophages - metabolism Macrophages - pathology Mice Molecular Bases of Disease Monocytes - metabolism Monocytes - pathology Neutrophils - metabolism Neutrophils - pathology Vascular Endothelial Growth Factor (VEGF) Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism
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