Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers

Oligodendroglioma is characterized by unique clinical, pathological, and genetic features. Recurrent losses of chromosomes 1p and 19q are strongly associated with this brain cancer but knowledge of the identity and function of the genes affected by these alterations is limited. We performed exome se...

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Veröffentlicht in:	The Journal of pathology 2012-01, Vol.226 (1), p.7-16
Hauptverfasser:	Yip, Stephen, Butterfield, Yaron S, Morozova, Olena, Chittaranjan, Suganthi, Blough, Michael D, An, Jianghong, Birol, Inanc, Chesnelong, Charles, Chiu, Readman, Chuah, Eric, Corbett, Richard, Docking, Rod, Firme, Marlo, Hirst, Martin, Jackman, Shaun, Karsan, Aly, Li, Haiyan, Louis, David N, Maslova, Alexandra, Moore, Richard, Moradian, Annie, Mungall, Karen L, Perizzolo, Marco, Qian, Jenny, Roldan, Gloria, Smith, Eric E, Tamura-Wells, Jessica, Thiessen, Nina, Varhol, Richard, Weiss, Samuel, Wu, Wei, Young, Sean, Zhao, Yongjun, Mungall, Andrew J, Jones, Steven JM, Morin, Gregg B, Chan, Jennifer A, Cairncross, J Gregory, Marra, Marco A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - pathology Capicua Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 19 - genetics Disease-Free Survival glioma Humans IDH1 Isocitrate Dehydrogenase - genetics Kaplan-Meier Estimate Mutation Neoplasm Grading next-generation sequencing oligodendroglioma Oligodendroglioma - genetics Oligodendroglioma - mortality Oligodendroglioma - pathology Repressor Proteins - genetics
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