Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

The renal organic cation transport system mediates the tubular secretion of cationic compounds including drugs, toxins and endogenous metabolites into urine. It consists of a membrane potential‐dependent organic cation transporter at the basolateral membrane and an H+/organic cation antiporter at th...

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Veröffentlicht in:	British journal of pharmacology 2011-12, Vol.164 (7), p.1817-1825
Hauptverfasser:	Yonezawa, Atsushi, Inui, Ken‐ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals brush‐border membrane H+/organic cation antiporter Humans kidney Large intestine metformin Organic Cation Transport Proteins - genetics Organic Cation Transport Proteins - metabolism organic cation transporter Pharmacogenetics Pharmacokinetics Polymorphism, Single Nucleotide renal tubular secretion Small intestine Themed Section: Reviews
Online-Zugang:	Volltext
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