Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer
Objectives Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Study Design Nine vulvar cancer patient...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2012-01, Vol.206 (1), p.89.e1-89.e5 |
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| creator | Hutteman, Merlijn, PhD van der Vorst, Joost R., MD Gaarenstroom, Katja N., MD, PhD Peters, Alexander A.W., MD, PhD Mieog, J. Sven D., MD Schaafsma, Boudewijn E., MD Löwik, Clemens W.G.M., PhD Frangioni, John V., MD, PhD van de Velde, Cornelis J.H., MD, PhD Vahrmeijer, Alexander L., MD, PhD |
| description | Objectives Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Study Design Nine vulvar cancer patients underwent the standard sentinel lymph node procedure using99m technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750, or 1000 μM of indocyanine green adsorbed to human serum albumin. Results Near-infrared fluorescence sentinel lymph node mapping was successful in all patients. A total of 14 sentinel lymph nodes (average, 1.6; range, 1–4) were detected: 14 radioactive (100%), 11 blue (79%), and 14 near-infrared fluorescent (100%). Conclusion This study demonstrates feasibility and accuracy of sentinel lymph node mapping using indocyanine green adsorbed to human serum albumin. Considering safety, cost, and pharmacy preferences, an indocyanine green adsorbed to human serum albumin concentration of 500 μM appears optimal for sentinel lymph node mapping in vulvar cancer. |
| doi_str_mv | 10.1016/j.ajog.2011.07.039 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3246078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002937811009562</els_id><sourcerecordid>S0002937811009562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c605t-35dabf53b89939eefaabc610e70a6e691c4799a36cc6623a6476109b3cf8d63d3</originalsourceid><addsrcrecordid>eNp9kkFr3DAQhUVpSbZp_kAPRZce7UqWLVtQAiW0TSCQQ1t6FGN5vJFrS0byLmx-fWU2TZscetEg5r15w8cQ8paznDMuPww5DH6bF4zznNU5E-oF2XCm6kw2snlJNoyxIlOibk7J6xiH9Vuo4oScFlxJwZTakJ-382Inew-L9Y76njqEkFnXBwjY0X7c-YDRoFtoTI91ONLxMM131PkO6QTzbN2W9j7Q_W7cQ6AGnMHwhrzqYYx4_lDPyI8vn79fXmU3t1-vLz_dZEayaslE1UHbV6JtlBIKsQdojeQMawYSpeKmrJUCIY2RshAgyzp1VStM33RSdOKMXBznzrt2wm5dNMCo52AnCAftweqnHWfv9NbvtShKyeomDSiOA0zwMQbsH72c6RWzHvSKWa-YNat1wpxM7_5NfbT84ZoE7x8EEA2MiaYzNv7VVZKrslzTPx51mBjtLQYdjcUEsLMBzaI7b_-_x8UzuxmtsynxFx4wDn4XXKKvuY6FZvrbegHrPXDOmKoS0N_1U7NI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hutteman, Merlijn, PhD ; van der Vorst, Joost R., MD ; Gaarenstroom, Katja N., MD, PhD ; Peters, Alexander A.W., MD, PhD ; Mieog, J. Sven D., MD ; Schaafsma, Boudewijn E., MD ; Löwik, Clemens W.G.M., PhD ; Frangioni, John V., MD, PhD ; van de Velde, Cornelis J.H., MD, PhD ; Vahrmeijer, Alexander L., MD, PhD</creator><creatorcontrib>Hutteman, Merlijn, PhD ; van der Vorst, Joost R., MD ; Gaarenstroom, Katja N., MD, PhD ; Peters, Alexander A.W., MD, PhD ; Mieog, J. Sven D., MD ; Schaafsma, Boudewijn E., MD ; Löwik, Clemens W.G.M., PhD ; Frangioni, John V., MD, PhD ; van de Velde, Cornelis J.H., MD, PhD ; Vahrmeijer, Alexander L., MD, PhD</creatorcontrib><description>Objectives Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Study Design Nine vulvar cancer patients underwent the standard sentinel lymph node procedure using99m technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750, or 1000 μM of indocyanine green adsorbed to human serum albumin. Results Near-infrared fluorescence sentinel lymph node mapping was successful in all patients. A total of 14 sentinel lymph nodes (average, 1.6; range, 1–4) were detected: 14 radioactive (100%), 11 blue (79%), and 14 near-infrared fluorescent (100%). Conclusion This study demonstrates feasibility and accuracy of sentinel lymph node mapping using indocyanine green adsorbed to human serum albumin. Considering safety, cost, and pharmacy preferences, an indocyanine green adsorbed to human serum albumin concentration of 500 μM appears optimal for sentinel lymph node mapping in vulvar cancer.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2011.07.039</identifier><identifier>PMID: 21963099</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma - diagnostic imaging ; Carcinoma - pathology ; Dose-Response Relationship, Drug ; Female ; Female genital diseases ; Fluorescent Dyes ; Gynecology. Andrology. Obstetrics ; Humans ; image-guided surgery ; Indocyanine Green ; Lymph Nodes - diagnostic imaging ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Medical sciences ; Middle Aged ; near-infrared fluorescence imaging ; Obstetrics and Gynecology ; Radionuclide Imaging ; Radiopharmaceuticals ; Sentinel Lymph Node Biopsy - methods ; sentinel lymph node mapping ; Spectroscopy, Near-Infrared - methods ; Technetium Tc 99m Aggregated Albumin ; Tumors ; vulvar cancer ; Vulvar Neoplasms - diagnostic imaging ; Vulvar Neoplasms - pathology</subject><ispartof>American journal of obstetrics and gynecology, 2012-01, Vol.206 (1), p.89.e1-89.e5</ispartof><rights>Mosby, Inc.</rights><rights>2012 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-35dabf53b89939eefaabc610e70a6e691c4799a36cc6623a6476109b3cf8d63d3</citedby><cites>FETCH-LOGICAL-c605t-35dabf53b89939eefaabc610e70a6e691c4799a36cc6623a6476109b3cf8d63d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937811009562$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25619448$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21963099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hutteman, Merlijn, PhD</creatorcontrib><creatorcontrib>van der Vorst, Joost R., MD</creatorcontrib><creatorcontrib>Gaarenstroom, Katja N., MD, PhD</creatorcontrib><creatorcontrib>Peters, Alexander A.W., MD, PhD</creatorcontrib><creatorcontrib>Mieog, J. Sven D., MD</creatorcontrib><creatorcontrib>Schaafsma, Boudewijn E., MD</creatorcontrib><creatorcontrib>Löwik, Clemens W.G.M., PhD</creatorcontrib><creatorcontrib>Frangioni, John V., MD, PhD</creatorcontrib><creatorcontrib>van de Velde, Cornelis J.H., MD, PhD</creatorcontrib><creatorcontrib>Vahrmeijer, Alexander L., MD, PhD</creatorcontrib><title>Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objectives Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Study Design Nine vulvar cancer patients underwent the standard sentinel lymph node procedure using99m technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750, or 1000 μM of indocyanine green adsorbed to human serum albumin. Results Near-infrared fluorescence sentinel lymph node mapping was successful in all patients. A total of 14 sentinel lymph nodes (average, 1.6; range, 1–4) were detected: 14 radioactive (100%), 11 blue (79%), and 14 near-infrared fluorescent (100%). Conclusion This study demonstrates feasibility and accuracy of sentinel lymph node mapping using indocyanine green adsorbed to human serum albumin. Considering safety, cost, and pharmacy preferences, an indocyanine green adsorbed to human serum albumin concentration of 500 μM appears optimal for sentinel lymph node mapping in vulvar cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - pathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Fluorescent Dyes</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>image-guided surgery</subject><subject>Indocyanine Green</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>near-infrared fluorescence imaging</subject><subject>Obstetrics and Gynecology</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Sentinel Lymph Node Biopsy - methods</subject><subject>sentinel lymph node mapping</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Technetium Tc 99m Aggregated Albumin</subject><subject>Tumors</subject><subject>vulvar cancer</subject><subject>Vulvar Neoplasms - diagnostic imaging</subject><subject>Vulvar Neoplasms - pathology</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkFr3DAQhUVpSbZp_kAPRZce7UqWLVtQAiW0TSCQQ1t6FGN5vJFrS0byLmx-fWU2TZscetEg5r15w8cQ8paznDMuPww5DH6bF4zznNU5E-oF2XCm6kw2snlJNoyxIlOibk7J6xiH9Vuo4oScFlxJwZTakJ-382Inew-L9Y76njqEkFnXBwjY0X7c-YDRoFtoTI91ONLxMM131PkO6QTzbN2W9j7Q_W7cQ6AGnMHwhrzqYYx4_lDPyI8vn79fXmU3t1-vLz_dZEayaslE1UHbV6JtlBIKsQdojeQMawYSpeKmrJUCIY2RshAgyzp1VStM33RSdOKMXBznzrt2wm5dNMCo52AnCAftweqnHWfv9NbvtShKyeomDSiOA0zwMQbsH72c6RWzHvSKWa-YNat1wpxM7_5NfbT84ZoE7x8EEA2MiaYzNv7VVZKrslzTPx51mBjtLQYdjcUEsLMBzaI7b_-_x8UzuxmtsynxFx4wDn4XXKKvuY6FZvrbegHrPXDOmKoS0N_1U7NI</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Hutteman, Merlijn, PhD</creator><creator>van der Vorst, Joost R., MD</creator><creator>Gaarenstroom, Katja N., MD, PhD</creator><creator>Peters, Alexander A.W., MD, PhD</creator><creator>Mieog, J. Sven D., MD</creator><creator>Schaafsma, Boudewijn E., MD</creator><creator>Löwik, Clemens W.G.M., PhD</creator><creator>Frangioni, John V., MD, PhD</creator><creator>van de Velde, Cornelis J.H., MD, PhD</creator><creator>Vahrmeijer, Alexander L., MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer</title><author>Hutteman, Merlijn, PhD ; van der Vorst, Joost R., MD ; Gaarenstroom, Katja N., MD, PhD ; Peters, Alexander A.W., MD, PhD ; Mieog, J. Sven D., MD ; Schaafsma, Boudewijn E., MD ; Löwik, Clemens W.G.M., PhD ; Frangioni, John V., MD, PhD ; van de Velde, Cornelis J.H., MD, PhD ; Vahrmeijer, Alexander L., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-35dabf53b89939eefaabc610e70a6e691c4799a36cc6623a6476109b3cf8d63d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - pathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Fluorescent Dyes</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>image-guided surgery</topic><topic>Indocyanine Green</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>near-infrared fluorescence imaging</topic><topic>Obstetrics and Gynecology</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Sentinel Lymph Node Biopsy - methods</topic><topic>sentinel lymph node mapping</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>Technetium Tc 99m Aggregated Albumin</topic><topic>Tumors</topic><topic>vulvar cancer</topic><topic>Vulvar Neoplasms - diagnostic imaging</topic><topic>Vulvar Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hutteman, Merlijn, PhD</creatorcontrib><creatorcontrib>van der Vorst, Joost R., MD</creatorcontrib><creatorcontrib>Gaarenstroom, Katja N., MD, PhD</creatorcontrib><creatorcontrib>Peters, Alexander A.W., MD, PhD</creatorcontrib><creatorcontrib>Mieog, J. Sven D., MD</creatorcontrib><creatorcontrib>Schaafsma, Boudewijn E., MD</creatorcontrib><creatorcontrib>Löwik, Clemens W.G.M., PhD</creatorcontrib><creatorcontrib>Frangioni, John V., MD, PhD</creatorcontrib><creatorcontrib>van de Velde, Cornelis J.H., MD, PhD</creatorcontrib><creatorcontrib>Vahrmeijer, Alexander L., MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hutteman, Merlijn, PhD</au><au>van der Vorst, Joost R., MD</au><au>Gaarenstroom, Katja N., MD, PhD</au><au>Peters, Alexander A.W., MD, PhD</au><au>Mieog, J. Sven D., MD</au><au>Schaafsma, Boudewijn E., MD</au><au>Löwik, Clemens W.G.M., PhD</au><au>Frangioni, John V., MD, PhD</au><au>van de Velde, Cornelis J.H., MD, PhD</au><au>Vahrmeijer, Alexander L., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>206</volume><issue>1</issue><spage>89.e1</spage><epage>89.e5</epage><pages>89.e1-89.e5</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objectives Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Study Design Nine vulvar cancer patients underwent the standard sentinel lymph node procedure using99m technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750, or 1000 μM of indocyanine green adsorbed to human serum albumin. Results Near-infrared fluorescence sentinel lymph node mapping was successful in all patients. A total of 14 sentinel lymph nodes (average, 1.6; range, 1–4) were detected: 14 radioactive (100%), 11 blue (79%), and 14 near-infrared fluorescent (100%). Conclusion This study demonstrates feasibility and accuracy of sentinel lymph node mapping using indocyanine green adsorbed to human serum albumin. Considering safety, cost, and pharmacy preferences, an indocyanine green adsorbed to human serum albumin concentration of 500 μM appears optimal for sentinel lymph node mapping in vulvar cancer.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>21963099</pmid><doi>10.1016/j.ajog.2011.07.039</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0002-9378 1097-6868 |
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| subjects | Adult Aged Biological and medical sciences Carcinoma - diagnostic imaging Carcinoma - pathology Dose-Response Relationship, Drug Female Female genital diseases Fluorescent Dyes Gynecology. Andrology. Obstetrics Humans image-guided surgery Indocyanine Green Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Lymphatic Metastasis Medical sciences Middle Aged near-infrared fluorescence imaging Obstetrics and Gynecology Radionuclide Imaging Radiopharmaceuticals Sentinel Lymph Node Biopsy - methods sentinel lymph node mapping Spectroscopy, Near-Infrared - methods Technetium Tc 99m Aggregated Albumin Tumors vulvar cancer Vulvar Neoplasms - diagnostic imaging Vulvar Neoplasms - pathology |
| title | Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer |
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