Axonal degeneration is mediated by the mitochondrial permeability transition pore

Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative process can cause permanent loss of function, so it represents a focus for neuroprotective...

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Veröffentlicht in:	The Journal of neuroscience 2011-01, Vol.31 (3), p.966-978
Hauptverfasser:	Barrientos, Sebastian A, Martinez, Nicolas W, Yoo, Soonmoon, Jara, Juan S, Zamorano, Sebastian, Hetz, Claudio, Twiss, Jeffery L, Alvarez, Jaime, Court, Felipe A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - metabolism Axons - pathology Blotting, Western Cells, Cultured Cyclophilins - metabolism Fluorescent Antibody Technique Male Mice Microscopy, Electron Mitochondria - metabolism Mitochondria - pathology Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Permeability Transition Pore Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurons - metabolism Neurons - pathology Peptidyl-Prolyl Isomerase F Rats Rats, Sprague-Dawley
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