A Common β1-Adrenergic Receptor Polymorphism Predicts Favorable Response to Rate-Control Therapy in Atrial Fibrillation

Objectives In this study, we evaluated the impact of 2 common β1-adrenergic receptor (β1-AR) polymorphisms ( G389R and S49G ) in response to ventricular rate control therapy in patients with atrial fibrillation (AF). Background Randomized studies have shown that ventricular rate control is an accept...

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Veröffentlicht in:	Journal of the American College of Cardiology 2012-01, Vol.59 (1), p.49-56
Hauptverfasser:	Parvez, Babar, MD, Chopra, Nagesh, MD, Rowan, Shane, MD, Vaglio, Joseph C., MD, Muhammad, Raafia, MD, Roden, Dan M., MD, Darbar, Dawood, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-1 Receptor Antagonists - therapeutic use Aged Anti-Arrhythmia Agents - therapeutic use atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - drug therapy Atrial Fibrillation - genetics beta-adrenergic receptor Cardiovascular Cohort Studies Confidence Intervals Dose-Response Relationship, Drug Drug Administration Schedule Electrocardiography - methods Female Follow-Up Studies genomics Heart Rate - drug effects Humans Internal Medicine Logistic Models Male Middle Aged Odds Ratio Polymorphism, Genetic polymorphisms Predictive Value of Tests Prospective Studies rate control Receptors, Adrenergic, beta-1 - genetics Registries Severity of Illness Index Treatment Outcome
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