Astrocytes Reverted to a Neural Progenitor‐like State with Transforming Growth Factor Alpha Are Sensitized to Cancerous Transformation

Gliomas, the most frequent primitive central nervous system tumors, have been suggested to originate from astrocytes or from neural progenitors/stem cells. However, the precise identity of the cells at the origin of gliomas remains a matter of debate because no pre‐neoplastic state has been yet iden...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2009-10, Vol.27 (10), p.2373-2382
Hauptverfasser:	Dufour, Christelle, Cadusseau, Josette, Varlet, Pascale, Surena, Anne‐Laure, de Faria, Giselle P, Dias‐Morais, Amelie, Auger, Nathalie, Léonard, Nadine, Daudigeos, Estelle, Dantas‐Barbosa, Carmela, Grill, Jacques, Lazar, Vladimir, Dessen, Philippe, Vassal, Gilles, Prevot, Vincent, Sharif, Ariane, Chneiweiss, Herve, Junier, Marie‐Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - metabolism Astrocytes - radiation effects Biochemistry, Molecular Biology Brain Neoplasms - chemically induced Brain Neoplasms - physiopathology Cell Dedifferentiation - drug effects Cell Dedifferentiation - physiology Cell Dedifferentiation - radiation effects Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - radiation effects Cells, Cultured Culture Media, Serum-Free - pharmacology Epidermal growth factor erbB Gamma Rays - adverse effects Glioma - chemically induced Glioma - physiopathology Life Sciences Metaplasia Mice Mice, Inbred C57BL Mice, Nude Radial glia Stem Cell Transplantation Stem Cells - drug effects Stem Cells - metabolism Stem Cells - radiation effects Stress, Physiological - physiology Stress, Physiological - radiation effects Transdifferentiation Transforming Growth Factor alpha - metabolism Transforming Growth Factor alpha - pharmacology
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