Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers

Motivation: Genome-wide mRNA profiling provides a snapshot of the global state of cells under different conditions. However, mRNA levels do not provide direct understanding of upstream regulatory mechanisms. Here, we present a new approach called Expression2Kinases (X2K) to identify upstream regulat...

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Veröffentlicht in:	Bioinformatics 2012-01, Vol.28 (1), p.105-111
Hauptverfasser:	Chen, Edward Y., Xu, Huilei, Gordonov, Simon, Lim, Maribel P., Perkins, Matthew H., Ma'ayan, Avi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioinformatics Biological and medical sciences Breast Cell Differentiation Chromatin Immunoprecipitation Drugs Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling General aspects Genome-Wide Association Study Humans Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Matrices Oligonucleotide Array Sequence Analysis Original Papers Profiling Regulatory Sequences, Nucleic Acid Signal Transduction Software Source code Transcription Factors - metabolism Upstream
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