Modulation of TCRβ surface expression during TCR revision

► Through TCR revision, autoreactive TCRs are replaced by those generated through post-thymic DNA rearrangement. ► Downmodulation of surface TCR expression initiates RAG re-expression and TCR revision. ► In Vβ5 transgenic mice, loss of surface TCR is not mediated by transgene loss or diminished expr...

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Veröffentlicht in:	Cellular immunology 2012-01, Vol.272 (2), p.124-129
Hauptverfasser:	Simmons, Kalynn B., Wubeshet, Maramawit, Ames, Kristina T., McMahan, Catherine J., Hale, J. Scott, Fink, Pamela J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - metabolism Down-Regulation - genetics Gene Expression - genetics Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Immune Tolerance - genetics Mice Mice, Transgenic Peripheral T cell tolerance Receptor revision Receptors, Antigen, T-Cell, alpha-beta - biosynthesis Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism TCR expression Transgenes - genetics
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