Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression
Background Relatives of patients with major depressive disorder (MDD) and people who experienced early-life adversity are at risk for MDD. The aim of our study was to investigate whether unaffected first-degree healthy relatives (UHRs) of patients with MDD show changes in white matter fibre connecti...
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| Veröffentlicht in: | Journal of psychiatry & neuroscience 2012, Vol.37 (1), p.37-45 |
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| creator | Frodl, Thomas, MD, MA Carballedo, Angela Fagan, Andrew J., PhD Lisiecka, Danuta, MSc, MA Ferguson, Yolande, MSc, MB Meaney, James F., MB |
| description | Background Relatives of patients with major depressive disorder (MDD) and people who experienced early-life adversity are at risk for MDD. The aim of our study was to investigate whether unaffected first-degree healthy relatives (UHRs) of patients with MDD show changes in white matter fibre connections compared with healthy controls and whether there are interactions between early-life adversity and these microstructural changes. Methods Unaffected, healthy first-degree relatives of patients with MDD and healthy controls without any family history for a psychiatric disease underwent high angular resolution diffusion imaging with 61 diffusion directions. Data were analyzed with tract-based spatial statistics, and findings were confirmed with tractography. Results Twenty-one UHRs and 24 controls participated in our study. The UHRs showed greater fractional anisotropy than controls in the body and splenium of the corpus callosum, inferior fronto-occipital fasciculus (IFO), left superior longitudinal fasciculus (SLF) and right fornix. The UHRs who experienced more early-life adversity had greater fractional anisotropy than those with less early-life adversity in the splenium of the corpus callosum, fornix, IFO and SLF; in controls, early-life adversity was found to be associated with decreased fractional anisotropy in these fibre tracts. Limitations Studying participants’ strategies for coping with early-life adversity would have been helpful. Crossing fibres in tracts are a general limitation of the method used. Conclusion Altogether, our findings provide evidence for greater fractional anisotropy in UHRs and for interaction between early-life adversity and family risk on white matter tracts involved in cognitive–emotional processes. Whether stronger neural fibre connections are associated with more resilience against depression needs to be addressed in future studies. |
| doi_str_mv | 10.1503/jpn.110028 |
| format | Article |
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The aim of our study was to investigate whether unaffected first-degree healthy relatives (UHRs) of patients with MDD show changes in white matter fibre connections compared with healthy controls and whether there are interactions between early-life adversity and these microstructural changes. Methods Unaffected, healthy first-degree relatives of patients with MDD and healthy controls without any family history for a psychiatric disease underwent high angular resolution diffusion imaging with 61 diffusion directions. Data were analyzed with tract-based spatial statistics, and findings were confirmed with tractography. Results Twenty-one UHRs and 24 controls participated in our study. The UHRs showed greater fractional anisotropy than controls in the body and splenium of the corpus callosum, inferior fronto-occipital fasciculus (IFO), left superior longitudinal fasciculus (SLF) and right fornix. The UHRs who experienced more early-life adversity had greater fractional anisotropy than those with less early-life adversity in the splenium of the corpus callosum, fornix, IFO and SLF; in controls, early-life adversity was found to be associated with decreased fractional anisotropy in these fibre tracts. Limitations Studying participants’ strategies for coping with early-life adversity would have been helpful. Crossing fibres in tracts are a general limitation of the method used. Conclusion Altogether, our findings provide evidence for greater fractional anisotropy in UHRs and for interaction between early-life adversity and family risk on white matter tracts involved in cognitive–emotional processes. Whether stronger neural fibre connections are associated with more resilience against depression needs to be addressed in future studies.</description><identifier>ISSN: 1180-4882</identifier><identifier>EISSN: 1488-2434</identifier><identifier>DOI: 10.1503/jpn.110028</identifier><identifier>PMID: 22008179</identifier><identifier>CODEN: JPNEEF</identifier><language>eng</language><publisher>Ottawa, ON: Canadian Medical Association</publisher><subject>Adult ; Adult and adolescent clinical studies ; Adult Survivors of Child Abuse ; Anisotropy ; Biological and medical sciences ; Brain - physiopathology ; Depression ; Depressive Disorder, Major - physiopathology ; Depressive Disorder, Major - psychology ; Development and progression ; Diagnostic imaging ; Diffusion Tensor Imaging ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Image Processing, Computer-Assisted ; Life Change Events ; Major depressive disorder ; Male ; Medical Education ; Medical sciences ; Mental depression ; Methods ; Middle Aged ; Mood disorders ; Nerve Fibers, Myelinated - physiology ; Neurology ; Neuropsychology ; Physiological aspects ; Psychiatry ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Research Paper ; Risk Factors ; Studies</subject><ispartof>Journal of psychiatry & neuroscience, 2012, Vol.37 (1), p.37-45</ispartof><rights>Canadian Medical Association</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Joule Inc.</rights><rights>Copyright Canadian Medical Association Jan 2012</rights><rights>2012 Canadian Medical Association 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c786t-f445f6ed19bac1dc426650a6fdb45633d0c462f26f792e5be0b89154ebfa1c7c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244497/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244497/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25472123$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22008179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frodl, Thomas, MD, MA</creatorcontrib><creatorcontrib>Carballedo, Angela</creatorcontrib><creatorcontrib>Fagan, Andrew J., PhD</creatorcontrib><creatorcontrib>Lisiecka, Danuta, MSc, MA</creatorcontrib><creatorcontrib>Ferguson, Yolande, MSc, MB</creatorcontrib><creatorcontrib>Meaney, James F., MB</creatorcontrib><title>Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression</title><title>Journal of psychiatry & neuroscience</title><addtitle>J Psychiatry Neurosci</addtitle><description>Background Relatives of patients with major depressive disorder (MDD) and people who experienced early-life adversity are at risk for MDD. The aim of our study was to investigate whether unaffected first-degree healthy relatives (UHRs) of patients with MDD show changes in white matter fibre connections compared with healthy controls and whether there are interactions between early-life adversity and these microstructural changes. Methods Unaffected, healthy first-degree relatives of patients with MDD and healthy controls without any family history for a psychiatric disease underwent high angular resolution diffusion imaging with 61 diffusion directions. Data were analyzed with tract-based spatial statistics, and findings were confirmed with tractography. Results Twenty-one UHRs and 24 controls participated in our study. The UHRs showed greater fractional anisotropy than controls in the body and splenium of the corpus callosum, inferior fronto-occipital fasciculus (IFO), left superior longitudinal fasciculus (SLF) and right fornix. The UHRs who experienced more early-life adversity had greater fractional anisotropy than those with less early-life adversity in the splenium of the corpus callosum, fornix, IFO and SLF; in controls, early-life adversity was found to be associated with decreased fractional anisotropy in these fibre tracts. Limitations Studying participants’ strategies for coping with early-life adversity would have been helpful. Crossing fibres in tracts are a general limitation of the method used. Conclusion Altogether, our findings provide evidence for greater fractional anisotropy in UHRs and for interaction between early-life adversity and family risk on white matter tracts involved in cognitive–emotional processes. Whether stronger neural fibre connections are associated with more resilience against depression needs to be addressed in future studies.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Adult Survivors of Child Abuse</subject><subject>Anisotropy</subject><subject>Biological and medical sciences</subject><subject>Brain - physiopathology</subject><subject>Depression</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Development and progression</subject><subject>Diagnostic imaging</subject><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Life Change Events</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Medical Education</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Neurology</subject><subject>Neuropsychology</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. 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Psychology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Life Change Events</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Medical Education</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Nerve Fibers, Myelinated - physiology</topic><topic>Neurology</topic><topic>Neuropsychology</topic><topic>Physiological aspects</topic><topic>Psychiatry</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Research Paper</topic><topic>Risk Factors</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frodl, Thomas, MD, MA</creatorcontrib><creatorcontrib>Carballedo, Angela</creatorcontrib><creatorcontrib>Fagan, Andrew J., PhD</creatorcontrib><creatorcontrib>Lisiecka, Danuta, MSc, MA</creatorcontrib><creatorcontrib>Ferguson, Yolande, MSc, MB</creatorcontrib><creatorcontrib>Meaney, James F., MB</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of psychiatry & neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frodl, Thomas, MD, MA</au><au>Carballedo, Angela</au><au>Fagan, Andrew J., PhD</au><au>Lisiecka, Danuta, MSc, MA</au><au>Ferguson, Yolande, MSc, MB</au><au>Meaney, James F., MB</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression</atitle><jtitle>Journal of psychiatry & neuroscience</jtitle><addtitle>J Psychiatry Neurosci</addtitle><date>2012</date><risdate>2012</risdate><volume>37</volume><issue>1</issue><spage>37</spage><epage>45</epage><pages>37-45</pages><issn>1180-4882</issn><eissn>1488-2434</eissn><coden>JPNEEF</coden><abstract>Background Relatives of patients with major depressive disorder (MDD) and people who experienced early-life adversity are at risk for MDD. The aim of our study was to investigate whether unaffected first-degree healthy relatives (UHRs) of patients with MDD show changes in white matter fibre connections compared with healthy controls and whether there are interactions between early-life adversity and these microstructural changes. Methods Unaffected, healthy first-degree relatives of patients with MDD and healthy controls without any family history for a psychiatric disease underwent high angular resolution diffusion imaging with 61 diffusion directions. Data were analyzed with tract-based spatial statistics, and findings were confirmed with tractography. Results Twenty-one UHRs and 24 controls participated in our study. The UHRs showed greater fractional anisotropy than controls in the body and splenium of the corpus callosum, inferior fronto-occipital fasciculus (IFO), left superior longitudinal fasciculus (SLF) and right fornix. The UHRs who experienced more early-life adversity had greater fractional anisotropy than those with less early-life adversity in the splenium of the corpus callosum, fornix, IFO and SLF; in controls, early-life adversity was found to be associated with decreased fractional anisotropy in these fibre tracts. Limitations Studying participants’ strategies for coping with early-life adversity would have been helpful. Crossing fibres in tracts are a general limitation of the method used. Conclusion Altogether, our findings provide evidence for greater fractional anisotropy in UHRs and for interaction between early-life adversity and family risk on white matter tracts involved in cognitive–emotional processes. Whether stronger neural fibre connections are associated with more resilience against depression needs to be addressed in future studies.</abstract><cop>Ottawa, ON</cop><pub>Canadian Medical Association</pub><pmid>22008179</pmid><doi>10.1503/jpn.110028</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Adult Survivors of Child Abuse Anisotropy Biological and medical sciences Brain - physiopathology Depression Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Development and progression Diagnostic imaging Diffusion Tensor Imaging Female Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Life Change Events Major depressive disorder Male Medical Education Medical sciences Mental depression Methods Middle Aged Mood disorders Nerve Fibers, Myelinated - physiology Neurology Neuropsychology Physiological aspects Psychiatry Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Research Paper Risk Factors Studies |
| title | Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression |
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