Synthesis, Properties, and Applications of Oligonucleotides Containing an RNA Dinucleotide Phosphorothiolate Linkage

RNA represents a prominent class of biomolecules. Present in all living systems, RNA plays many essential roles in gene expression, regulation, and development. Accordingly, many biological processes depend on the accurate enzymatic processing, modification, and cleavage of RNA. Understanding the ca...

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Veröffentlicht in:	Accounts of chemical research 2011-12, Vol.44 (12), p.1257-1269
Hauptverfasser:	Li, Nan-Sheng, Frederiksen, John K, Piccirilli, Joseph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomolecules Cleavage Enzymes Gene expression Isomerism Linkages Models, Molecular Nucleic Acid Conformation Oligonucleotides Organophosphorus Compounds - chemistry Phosphorothioate Oligonucleotides - chemical synthesis Phosphorothioate Oligonucleotides - chemistry Ribonucleic acids RNA - chemical synthesis RNA - chemistry Synthesis
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