The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary microcephaly (MCPH). Here, we show that human STIL has an asymmetric localization to the daughter centriole and is required for procentriole formation. STIL leve...

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Veröffentlicht in:	The EMBO journal 2011-11, Vol.30 (23), p.4790-4804
Hauptverfasser:	Tang, Chieh-Ju C, Lin, Shin-Yi, Hsu, Wen-Bin, Lin, Yi-Nan, Wu, Chien-Ting, Lin, Yu-Chih, Chang, Ching-Wen, Wu, Kuo-Sheng, Tang, Tang K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biogenesis Cattle Cell cycle Cell Cycle - physiology Cell Cycle Proteins - metabolism Cell Division - physiology Cells, Cultured Centrioles - genetics Centrioles - metabolism Centrioles - pathology centrosome duplication EMBO05 EMBO06 HEK293 Cells HeLa Cells Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism MCPH microcephaly Microcephaly - genetics Microcephaly - physiopathology Microscopy, Confocal Microscopy, Fluorescence Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mutation procentriole formation Protein Binding Proteins
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