Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

Amyotrophic lateral sclerosis (ALS) is a progressive paralyzing disease characterized by tissue oxidative damage and motor neuron degeneration. This study investigated the in vivo effect of diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)), which is an orally bioavailable, blood-br...

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Veröffentlicht in:	The Journal of biological chemistry 2011-12, Vol.286 (51), p.44035-44044
Hauptverfasser:	Soon, Cynthia P.W., Donnelly, Paul S., Turner, Bradley J., Hung, Lin W., Crouch, Peter J., Sherratt, Nicki A., Tan, Jiang-Li, Lim, Nastasia K.-H., Lam, Linh, Bica, Laura, Lim, SinChun, Hickey, James L., Morizzi, Julia, Powell, Andrew, Finkelstein, David I., Culvenor, Janetta G., Masters, Colin L., Duce, James, White, Anthony R., Barnham, Kevin J., Li, Qiao-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis - metabolism Animals Antioxidants - chemistry Astrocytes - cytology Copper - chemistry CuII(atsm) Disease Models, Animal DNA-Binding Proteins - pharmacology Male Mice Mice, Inbred C57BL Mice, Transgenic Microglia - cytology Neurobiology Neurodegenerative Diseases Neurodegenerative Diseases - embryology Neurons - metabolism Organometallic Compounds - chemistry Oxidative Stress Oxygen - chemistry Peroxynitrite Peroxynitrous Acid - metabolism SODG93A Spinal Cord - pathology Superoxide Dismutase (SOD) Superoxide Dismutase - genetics Superoxide Dismutase-1 TDP-43 Thiosemicarbazones - chemistry Transgenes Transgenic Mice
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