Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription

The factors and mechanisms underlying the differential activity and regulation of eukaryotic RNA polymerase II on different types of core promoters have remained elusive. Here we show that the architectural factor HMGA1 and the Mediator coregulator complex cooperate to enhance basal transcription fr...

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Veröffentlicht in:	Genes & development 2011-12, Vol.25 (23), p.2513-2524
Hauptverfasser:	Xu, Muyu, Sharma, Priyanka, Pan, Songqin, Malik, Sohail, Roeder, Robert G, Martinez, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	HEK293 Cells HeLa Cells HMGA Proteins - genetics HMGA Proteins - physiology Humans Mediator Complex - genetics Mediator Complex - physiology Promoter Regions, Genetic Research Paper TATA Box TATA-Box Binding Protein - genetics TATA-Box Binding Protein - metabolism Transcription Factor TFIID - genetics Transcription Factor TFIID - metabolism Transcription, Genetic Transfection
Online-Zugang:	Volltext
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