Drug−disease interaction: Crohn's disease elevates verapamil plasma concentrations but reduces response to the drug proportional to disease activity

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Inflammatory conditions such as Crohn's disease are associated with cardiovascular complications. Inflammation also substantially reduces clearance of some cardiovascular drugs. It has also been shown that in rheumatoid arthritis, an elevation in verap...

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Veröffentlicht in:	British journal of clinical pharmacology 2011-11, Vol.72 (5), p.787-797
Hauptverfasser:	Sanaee, Forough, Clements, John D., Waugh, Alistair W. G., Fedorak, Richard N., Lewanczuk, Richard, Jamali, Fakhreddin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antiarythmic agents Area Under Curve Biological and medical sciences Calcium Channel Blockers - pharmacokinetics Calcium Channel Blockers - pharmacology calcium channels Cardiovascular system Case-Control Studies Crohn Disease - metabolism Crohn's disease Drug Interactions Female Gastroenterology. Liver. Pancreas. Abdomen Humans inflammation Male Medical sciences Metabolic Clearance Rate Middle Aged Other diseases. Semiology Pharmacokinetic Dynamic Relationships Pharmacology. Drug treatments PK−PD relationship receptor down regulation reduced response Severity of Illness Index Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Verapamil - pharmacokinetics Verapamil - pharmacology Young Adult
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