Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression

Cyclin D1 regulates cell proliferation and is a candidate molecular target for breast cancer therapy. This study addresses whether Cyclin D1 is indispensable for ErbB2-associated mammary tumor initiation and progression using a breast cancer model in which this cell-cycle regulator can be geneticall...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011-12, Vol.71 (24), p.7513-7524
Hauptverfasser:	QIAN ZHANG, SAKAMOTO, Kazuhito, CHENGBAO LIU, TRIPLETT, Aleata A, LIN, Wan-Chi, RUI, Hallgeir, WANER, Kay-Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Blotting, Western Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation Cells, Cultured Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin D3 - genetics Cyclin D3 - metabolism Disease Progression Female Humans Immunohistochemistry Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - pathology Medical sciences Mice Mice, Knockout Mice, Transgenic NIH 3T3 Cells Pharmacology. Drug treatments Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism RNA Interference Tumors
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