C5a regulates NKT and NK cell functions in sepsis

Complement, NKT, and NK cells play critical roles in the first line defense against pathogens. Functional roles for both C5a receptors, that is, complement receptor C5a (C5aR) and C5a receptor-like 2 (C5L2), in sepsis have been demonstrated. However, the role of C5a in innate lymphocyte activation d...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-12, Vol.187 (11), p.5805-5812
Hauptverfasser:	Fusakio, Michael E, Mohammed, Javid P, Laumonnier, Yves, Hoebe, Kasper, Köhl, Jörg, Mattner, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Separation Complement C5a - immunology Complement C5a - metabolism Escherichia Flow Cytometry Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism Real-Time Polymerase Chain Reaction Receptor, Anaphylatoxin C5a - immunology Receptor, Anaphylatoxin C5a - metabolism Reverse Transcriptase Polymerase Chain Reaction Sepsis - immunology Sepsis - metabolism
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